RGD Reference Report - Cytosolic phospholipase A2 in rat decidual cells: evidence for its role in decidualization. - Rat Genome Database

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Cytosolic phospholipase A2 in rat decidual cells: evidence for its role in decidualization.

Authors: Kurusu, S  Endo, M  Madarame, H  Kawaminami, M  Hashimoto, I 
Citation: Kurusu S, etal., FEBS Lett. 1999 Feb 12;444(2-3):235-8.
RGD ID: 1642479
Pubmed: PMID:10050766   (View Abstract at PubMed)

We investigated the existence and possible role of cytosolic phospholipase A2 (cPLA2) in rat decidualized uteri. PLA2 activity in the cytosol of a decidualized uterine horn, induced by intraluminal oil infusion, was significantly higher than that in contralateral intact horn. The activity was almost completely depressed by cPLA2 inhibitors including arachidonyl trifluoromethyl ketone (ATK). The immunoreactive signals for cPLA2 were intense in decidua and glandular epithelial cells. In vivo administration of ATK (0.1-100 microg) caused a dose-dependent inhibition of decidualization. These results show the presence of cPLA2 and its probable implication in decidualization in rat uterus.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
decidualization  IMP 1642479 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pla2g4a  (phospholipase A2 group IVA)


Additional Information