RGD Reference Report - Detection of C-type natriuretic peptide in human circulation and marked increase of plasma CNP level in septic shock patients. - Rat Genome Database

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Detection of C-type natriuretic peptide in human circulation and marked increase of plasma CNP level in septic shock patients.

Authors: Hama, N  Itoh, H  Shirakami, G  Suga, S  Komatsu, Y  Yoshimasa, T  Tanaka, I  Mori, K  Nakao, K 
Citation: Hama N, etal., Biochem Biophys Res Commun. 1994 Feb 15;198(3):1177-82.
RGD ID: 1642297
Pubmed: PMID:8117275   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1994.1166   (Journal Full-text)

We have previously reported that C-type natriuretic peptide (CNP), the third member of natriuretic family, was produced in vascular endothelial cells and hypothesized that CNP might be a local regulator of vascular tone and/or growth from endothelial cells. In order to clarify the pathophysiological significance of CNP in humans, we examined the presence of CNP in human circulation and determined plasma levels of CNP in patients with various cardiovascular disorders. The plasma level of CNP in healthy persons was 1.4 +/- 0.6 fmol/ml (n = 13). The plasma level of CNP was markedly increased in patients with septic shock (13.2 +/- 10.1 fmol/ml, n = 11), while there was no alteration in patients with congestive heart failure or hypertension. There was two-fold increase of the plasma CNP level in patients with chronic renal failure. These results indicate that CNP, which can be considered as an endothelium-derived relaxing peptide, is detectable in human circulation and suggest the pathophysiological significance of endothelial CNP in humans.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
end stage renal disease  IEP 1642297protein:increased expression:plasmaRGD 
end stage renal disease  ISONPPC (Homo sapiens)1642297; 1642297protein:increased expression:plasmaRGD 
toxic shock syndrome  IEP 1642297protein:increased expression:plasmaRGD 
toxic shock syndrome  ISONPPC (Homo sapiens)1642297; 1642297protein:increased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Nppc  (natriuretic peptide C)

Genes (Mus musculus)
Nppc  (natriuretic peptide type C)

Genes (Homo sapiens)
NPPC  (natriuretic peptide C)


Additional Information