RGD Reference Report - The association of brain natriuretic peptide and insulin resistance in obesity-related hypertension. - Rat Genome Database

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The association of brain natriuretic peptide and insulin resistance in obesity-related hypertension.

Authors: Tekes, S  Cikim, AS 
Citation: Tekes S and Cikim AS, J Hum Hypertens. 2007 Jul;21(7):546-50. Epub 2007 Mar 29.
RGD ID: 1642192
Pubmed: PMID:17392814   (View Abstract at PubMed)
DOI: DOI:10.1038/sj.jhh.1002194   (Journal Full-text)

Hypertension is frequently associated with obesity and natriuretic peptide levels are reported to decrease in obese subjects. Both the lower brain natriuretic peptide (BNP) concentration and insulin resistance are suggested to be associated with hypertension. However, their involvement in obesity-related hypertension has not been clearly defined. Forty-four obese women (21 normotensive and 23 hypertensive) and 25 healthy women matched for age were included in the study. Anthropometrical parameters were determined. Serum BNP, fasting insulin and glucose concentrations, and lipid parameters were evaluated. Insulin resistance was calculated using Homeostasis Model Assessment (HOMA) and Quantative Insulin Sensitivity Check Index (QUICKI) formulations. Within the obese groups, HOMA and QUICKI reflected the increased insulin resistance in hypertensive obese subjects with a significant correlation to blood pressure. The decrease in BNP in the obese groups was in favour of the hypertensive obese subjects (31.43+/-6.43; 26.36+/-4.29; and 17.51+/-3.08 pg/ml, respectively) with a fractional statistical significance between the hypertensive obese group and the controls (P=0.047). Only for the obese hypertensive group, fasting glucose, HOMA and QUICKI were significantly correlated with BNP. Moreover, fasting plasma glucose (R(2)=0.22, P=0.007) and fasting plasma insulin (R(2)=0.39, P=0.03) were independently correlated with BNP only for the obese hypertensive group. It can be concluded that the decrease in BNP concentrations in the obese hypertensive subjects seem to be well correlated with the insulin resistance.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Insulin Resistance  IEP 1642192associated with Obesity and Hypertension and protein:decreased expression:serumRGD 
Insulin Resistance  ISONPPB (Homo sapiens)1642192; 1642192associated with Obesity and Hypertension and protein:decreased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Nppb  (natriuretic peptide B)

Genes (Mus musculus)
Nppb  (natriuretic peptide type B)

Genes (Homo sapiens)
NPPB  (natriuretic peptide B)


Additional Information