RGD Reference Report - Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. - Rat Genome Database

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Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.

Authors: Crocq, MA  Mant, R  Asherson, P  Williams, J  Hode, Y  Mayerova, A  Collier, D  Lannfelt, L  Sokoloff, P  Schwartz, JC 
Citation: Crocq MA, etal., J Med Genet. 1992 Dec;29(12):858-60.
RGD ID: 1626357
Pubmed: PMID:1362221   (View Abstract at PubMed)
PMCID: PMC1016201   (View Article at PubMed Central)

Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
schizophrenia susceptibilityIAGP 1626357DNA:polymorphism:CDS:BalI polymorphism more ...RGD 
schizophrenia susceptibilityISODRD3 (Homo sapiens)1626357; 1626357 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Drd3  (dopamine receptor D3)

Genes (Mus musculus)
Drd3  (dopamine receptor D3)

Genes (Homo sapiens)
DRD3  (dopamine receptor D3)


Additional Information