RGD Reference Report - Induction of the adipose differentiation-related protein in liver of etomoxir-treated rats. - Rat Genome Database

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Induction of the adipose differentiation-related protein in liver of etomoxir-treated rats.

Authors: Steiner, S  Wahl, D  Mangold, BL  Robison, R  Raymackers, J  Meheus, L  Anderson, NL  Cordier, A 
Citation: Steiner S, etal., Biochem Biophys Res Commun. 1996 Jan 26;218(3):777-82.
RGD ID: 1625757
Pubmed: PMID:8579590   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1996.0138   (Journal Full-text)

The effects of etomoxir, an irreversible carnitine palmitoyltransferase I inhibitor, on the liver protein pattern and on liver morphology were examined by two-dimensional gel electrophoresis in female Sprague-Dawley rats treated with 125 mg/kg/day etomoxir for 28 days. In livers of treated animals a protein spot was found which was not present in controls. The spot was identified by internal amino acid sequence analysis as the adipose differentiation-related protein (ADRP). The expression of ADRP in liver is a novel finding as the protein has been described previously as adipocyte-specific. Additionally we found histopathologic evidence of lipid accumulation in the livers of etomoxir rats. The data show that for each treated rat there was a good correlation between ADRP levels and degree of lipid droplet formation. This observation may suggest a potential relationship between drug-induced expression of ADRP in liver and lipid accumulation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to xenobiotic stimulus  IEP 1625757 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Plin2  (perilipin 2)


Additional Information