RGD Reference Report - Adrenomedullin as a sensitive marker for coronary and peripheral arterial complications in patients with atherosclerotic risks. - Rat Genome Database

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Adrenomedullin as a sensitive marker for coronary and peripheral arterial complications in patients with atherosclerotic risks.

Authors: Suzuki, Y  Horio, T  Nonogi, H  Hayashi, T  Kitamura, K  Eto, T  Kangawa, K  Kawano, Y 
Citation: Suzuki Y, etal., Peptides. 2004 Aug;25(8):1321-6.
RGD ID: 1625302
Pubmed: PMID:15350700   (View Abstract at PubMed)
DOI: DOI:10.1016/j.peptides.2004.04.007   (Journal Full-text)

Plasma adrenomedullin (AM) levels are elevated in various pathological states including cardiovascular and inflammatory diseases. The present study investigated whether an increased AM level is a marker of vascular complications in patients with atherosclerotic risks. In 114 patients with cardiovascular risks and/or diseases including ischemic heart disease (IHD) and peripheral arterial disease (PAD), plasma AM concentration and other inflammatory markers such as high sensitive C-reactive protein (CRP) and interleukin (IL)-6 were examined. The plasma AM level was not altered by the absence or presence of each of four major risk factors, i.e., hypertension, diabetes mellitus, hyperlipidemia, and smoking and its level was not significantly correlated with blood pressure, plasma glucose, or serum lipid levels. The patients with IHD had a significantly higher concentration of plasma AM than those without IHD. The AM level in subjects with PAD was also increased significantly compared with those without PAD. The plasma AM was strongly correlated with inflammatory parameters such as CRP and IL-6. Among AM, CRP, and IL-6, however, only AM was an independent predictor for both IHD and PAD by multiple logistic regression analysis. Our findings suggest the possibility that plasma AM is a novel sensitive marker for the presence of vascular lesions in patients with atherosclerotic risks.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Myocardial Ischemia  IEP 1625302protein:increased expression:plasmaRGD 
Myocardial Ischemia  ISOADM (Homo sapiens)1625302; 1625302protein:increased expression:plasmaRGD 
peripheral vascular disease  IEP 1625302protein:increased expression:plasmaRGD 
peripheral vascular disease  ISOADM (Homo sapiens)1625302; 1625302protein:increased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Adm  (adrenomedullin)

Genes (Mus musculus)
Adm  (adrenomedullin)

Genes (Homo sapiens)
ADM  (adrenomedullin)


Additional Information