RGD Reference Report - The haplotypes of the IRS-2 gene affect insulin sensitivity in Japanese patients with type 2 diabetes. - Rat Genome Database

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The haplotypes of the IRS-2 gene affect insulin sensitivity in Japanese patients with type 2 diabetes.

Authors: Okazawa, K  Yoshimasa, Y  Miyamoto, Y  Takahashi-Yasuno, A  Miyawaki, T  Masuzaki, H  Hayashi, T  Hosoda, K  Inoue, G  Nakao, K 
Citation: Okazawa K, etal., Diabetes Res Clin Pract. 2005 Apr;68(1):39-48.
RGD ID: 1625025
Pubmed: PMID:15811564   (View Abstract at PubMed)
DOI: DOI:10.1016/j.diabres.2004.08.009   (Journal Full-text)

A commonly occurring nucleotide polymorphism of the insulin-receptor substrate 2 (IRS-2) gene at amino acid 1057 from Glycine to Asparaginic acid (G1057D) was recently shown to be a determinant of insulin sensitivity in both glucose-tolerant individuals and those with type 2 diabetes. With respect to the latter, the IRS-2 D1057 allele increase the risk of insulin resistance among obese individuals. After we reconstructed haplotypes from the G1057D variant and the -769C/T replacement that was newly identified, we investigated the possibility that the IRS-2 gene affects insulin sensitivity in Japanese glucose-tolerant subjects (n = 260) and type 2 diabetic patients (n = 123). We did not find that the D1057 allele and haplotype pairs were associated with the risk of diabetes. However, type 2 diabetic patients, particularly obese patients, carrying the D1057 allele and the CA haplotype were associated with insulin resistance. Furthermore, we suggested that the TG and CG haplotypes might have a protective role against insulin resistance. This observation raises the possibility that both the IRS-2 D1057 allele and the CA haplotype are useful genetic markers for identifying obese individuals who are particularly susceptible to insulin resistance.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Insulin Resistance  IAGP 1625025DNA:polymorphism:exon:G1057DRGD 
Insulin Resistance  ISOIRS2 (Homo sapiens)1625025; 1625025DNA:polymorphism:exon:G1057DRGD 

Objects Annotated

Genes (Rattus norvegicus)
Irs2  (insulin receptor substrate 2)

Genes (Mus musculus)
Irs2  (insulin receptor substrate 2)

Genes (Homo sapiens)
IRS2  (insulin receptor substrate 2)


Additional Information