RGD Reference Report - Association of melanin-concentrating hormone receptor 1 5' polymorphism with early-onset extreme obesity. - Rat Genome Database

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Association of melanin-concentrating hormone receptor 1 5' polymorphism with early-onset extreme obesity.

Authors: Bell, CG  Meyre, D  Samson, C  Boyle, C  Lecoeur, C  Tauber, M  Jouret, B  Jaquet, D  Levy-Marchal, C  Charles, MA  Weill, J  Gibson, F  Mein, CA  Froguel, P  Walley, AJ 
Citation: Bell CG, etal., Diabetes. 2005 Oct;54(10):3049-55.
RGD ID: 1624359
Pubmed: PMID:16186414   (View Abstract at PubMed)

Murine models have been highly effective in identifying the monogenic forms of human obesity discovered to date. Melanin-concentrating hormone receptor 1 (MCHR1) has been shown to be significant in the downstream orexigenic activity of the leptin-melanocortin pathway by such models. In this study, the human MCHR1 gene was extensively characterized by sequencing 3.5 kb of coding, untranslated and intronic regions plus 1 kb of putative promoter region in 180 morbidly obese adults and 87 morbidly obese children, a total of >2.4 Mb of sequencing. Thirty-nine single nucleotide polymorphisms (SNPs) were found, seven of which encode an amino acid change. One mutation, R248Q, appeared to cosegregate with the obesity trait in one pedigree but was also found to be a rare polymorphism in control samples. To investigate the possible polygenic role of MCHR1, the six common SNPs (minor allele frequency >5%) found in the sequenced regions were then screened in 557 morbidly obese adults, 552 obese children, and 1,195 nonobese nondiabetic control subjects. The plausible promoter SNP, rs133068, was found to be associated with protection against obesity in obese children only (allele frequency P = 0.006 and genotype frequency P = 0.004). Most significant results were found when using a dominant model (P = 0.001, odds ratio 0.695 [95% CI 0.560-0.863]). However, similar associations were found when both adults and children were analyzed together (P = 0.006, 0.783 [0.658-0.930]), suggesting that severe forms of obesity with early onset may be associated with SNPs in MCHR1.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
morbid obesity onsetIAGP 1624359DNA:SNP:promoterRGD 
morbid obesity onsetISOMCHR1 (Homo sapiens)1624359; 1624359DNA:SNP:promoterRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mchr1  (melanin-concentrating hormone receptor 1)

Genes (Mus musculus)
Mchr1  (melanin-concentrating hormone receptor 1)

Genes (Homo sapiens)
MCHR1  (melanin concentrating hormone receptor 1)


Additional Information