RGD Reference Report - Clonidine-Induced Heat-Shock Protein Expression in Rat Aorta. - Rat Genome Database

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Clonidine-Induced Heat-Shock Protein Expression in Rat Aorta.

Authors: Moen, RJ  La Voi, KP  Zhang, M  Blake, MJ 
Citation: Moen RJ, etal., J Cardiovasc Pharmacol Ther. 1998 Apr;3(2):171-184.
RGD ID: 1624219
Pubmed: PMID:10684495   (View Abstract at PubMed)
DOI: DOI:10.1053/jcpt.1998.0171   (Journal Full-text)

BACKGROUND: Restraint-stress and administration of drugs that precipitate hypertension induce heat-shock protein (HSP) expression in the aorta. The exact mechanism supporting this hypertension-related HSP response is unclear because HSP induction is blocked by receptor-selective and nonselective antihypertensive agents. METHODS AND RESULTS: To identify mechanisms contributing to the pharmacological/physiological regulation of the HSP response in cardiovascular tissues, we administered clonidine to awake and freely moving animals to determine its effect on HSP expression in vivo. Inconsistent with previous work, we found that clonidine produced a dose-dependent and transient increase in HSP70 mRNA levels in the aorta. No other tissue examined displayed an HSP response after clonidine administration. Clonidine-induced HSP expression was not restricted to the HSP70 family; HSP89alpha, HSP89beta, and HSP60 were also induced. Interestingly, no heat-shock element-binding activity was observed after clonidine administration, suggesting that unusual transcriptional regulatory mechanisms mediate this response. Yohimbine and nifedipine blocked HSP70 mRNA expression, whereas isoproterenol, mecamylamine, and reserpine had no effect. CONCLUSIONS: The functional consequence of HSP expression in cardiovascular tissues may be to alter the responsiveness of cells in these tissues to subsequent drug or stress exposures, thereby implicating the HSP response as an important component of cardiovascular homeostasis. If so, treatment of mammalian organisms with drugs capable of inducting selective HSP expression in vascular tissue may alter the progression of cardiovascular disease processes.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to xenobiotic stimulus  IEP 1624219 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hspd1  (heat shock protein family D (Hsp60) member 1)


Additional Information