RGD Reference Report - Impact of alpha-tocopherol and vitamin C on endothelial markers in rats with streptozotocin-induced diabetes. - Rat Genome Database

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Impact of alpha-tocopherol and vitamin C on endothelial markers in rats with streptozotocin-induced diabetes.

Authors: Haidara, MA  Khloussy, H  Ammar, H  Aal Kassem, LA 
Citation: Haidara MA, etal., Med Sci Monit. 2004 Feb;10(2):BR41-6.
RGD ID: 1601646
Pubmed: PMID:14737039   (View Abstract at PubMed)

BACKGROUND: Overloads of reactive oxygen species in diabetes are associated with a number of pathological conditions, such as endothelial damage, which plays an important role in the initial stage of atherosclerosis. Plasma soluble thrombomodulin (sTM) and von Willebrand factor (vWF) have been found to be important markers of endothelial dysfunction. MATERIAL/METHODS: 33 male Wistar rats were used for this experiment. All rats received standard rat chow and water. 25 rats were made diabetic by intra peritoneal injection of streptozotocin (STZ) (65 mg/kg) and divided into three groups. Group I was allowed free access to food and water, Group II received 30 mg vitamin C daily, and Group III received a-tocopherol in a dose of 600 mg/kg body weight. RESULTS: At the end of the experimental period, there was significant elevation of sTM, vWF, fibrinogen, systolic blood pressure, and mean arterial blood pressure (MAP); however, there was a significant decrease in serum HDL cholesterol in the diabetic group in comparison to controls. Administration of antioxidants (vitamin C and a-tocopherol) caused attenuation of the endothelial damage, as vitamin C administration caused a significant decrease in sTM, vWF, fibrinogen and increased HDL-cholesterol, while a-tocopherol caused a significant decrease in vWF and sTM. Both vitamin C and a-tocopherol caused a significant decrease in systolic blood pressure and mean arterial pressure. CONCLUSIONS: Our results suggest that administration of antioxidants may ameliorate the risk of thrombo-embolism in diabetes associated with hypertension.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension treatmentISOThbd (Rattus norvegicus)1601646; 1601646associated with Experimental Diabetes MellitusRGD 
hypertension treatmentIEP 1601646; 1601646associated with Experimental Diabetes MellitusRGD 
hypertension treatmentISOVwf (Rattus norvegicus)1601646; 1601646associated with Experimental Diabetes MellitusRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to L-ascorbic acid  IEP 1601646 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Thbd  (thrombomodulin)
Vwf  (von Willebrand factor)

Genes (Mus musculus)
Thbd  (thrombomodulin)
Vwf  (Von Willebrand factor)

Genes (Homo sapiens)
THBD  (thrombomodulin)
VWF  (von Willebrand factor)


Additional Information