RGD Reference Report - Chronic intermittent hypoxia alters hypothalamic transcription of genes involved in metabolic regulation. - Rat Genome Database

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Chronic intermittent hypoxia alters hypothalamic transcription of genes involved in metabolic regulation.

Authors: Volgin, DV  Kubin, L 
Citation: Volgin DV and Kubin L, Auton Neurosci. 2006 Jun 30;126-127:93-9. Epub 2006 May 26.
RGD ID: 1601380
Pubmed: PMID:16730240   (View Abstract at PubMed)
DOI: DOI:10.1016/j.autneu.2006.03.013   (Journal Full-text)

Epidemiological studies show that the obstructive sleep apnea syndrome (OSAS) is strongly associated with obesity, hypertension and diabetes, the three conditions characteristic of the metabolic syndrome. Since metabolic disorders usually involve altered homeostatic mechanisms both centrally and peripherally, it is likely that so it is in OSAS, but the underlying mechanisms remain largely unknown. We used an established rodent model to test whether chronic intermittent hypoxia (CIH) similar to that experienced by OSAS patients leads to distinct and relevant for metabolic regulation transcriptional changes in the posterior hypothalamus. Using quantitative reverse transcription-polymerase chain reaction, we found that rats exposed to CIH for 35 days (n=9) had twice higher levels of the adrenergic alpha2A receptor mRNA than the rats simultaneously submitted to a matching sham treatment (n=9). The mRNA levels of three members of the family of signal transducers and activators of transcription, STAT1, STAT3 and STAT5b, were also increased 2-4 times. The increases occurred only in the perifornical region, whereas no changes were detected in the ventromedial region comprising the ventromedial and arcuate nuclei or the dorsomedial region comprising the dorsomedial and paraventricular nuclei. These results show that, at least at the transcriptional level, CIH exerts a distinct and regionally selective central effect on the expression of selected mRNAs involved in metabolic regulation through adrenergic, leptinergic and inflammatory pathways.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hypoxia  ISOStat5b (Rattus norvegicus)1601380; 1601380mRNA:increased expression:perifornical nucleusRGD 
Hypoxia  IEP 1601380mRNA:increased expression:perifornical nucleusRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to hypoxia  IEP 1601380 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Stat5b  (signal transducer and activator of transcription 5B)

Genes (Mus musculus)
Stat5b  (signal transducer and activator of transcription 5B)

Genes (Homo sapiens)
STAT5B  (signal transducer and activator of transcription 5B)


Additional Information