RGD Reference Report - Relation of alleles of the sodium-potassium adenosine triphosphatase alpha 2 gene with blood pressure and lead exposure. - Rat Genome Database

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Relation of alleles of the sodium-potassium adenosine triphosphatase alpha 2 gene with blood pressure and lead exposure.

Authors: Glenn, BS  Stewart, WF  Schwartz, BS  Bressler, J 
Citation: Glenn BS, etal., Am J Epidemiol. 2001 Mar 15;153(6):537-45.
RGD ID: 1601254
Pubmed: PMID:11257061   (View Abstract at PubMed)

Lead is associated with elevated blood pressure, although the mechanism of action is unknown. Genetic differences in sodium-potassium adenosine triphosphatase (Na(+)-K(+)ATPase) could explain some of the variation in the strength of the blood pressure-blood lead relation that has been observed in previous studies. In 1996-1997, the authors studied the association of blood pressure, hypertension prevalence, and polymorphisms in the gene for the alpha 2 subunit of Na(+)-K(+)ATPase (ATP1A2) among 220 former organolead manufacturing workers from New Jersey. Subjects were genotyped for a restriction fragment length polymorphism (RFLP) on the ATP1A2 gene. The association between blood lead and blood pressure was stronger among persons who were homozygous for the variant allele. Genotype was also associated with hypertension (adjusted odds ratio = 7.7; 95% confidence interval: 1.9, 31.4). Finally, the variant allele was 1.8 times more common among African Americans than among Caucasians. The RFLP may indicate susceptibility to the effect of lead on blood pressure. Moreover, the alpha 2 gene (or a closely linked gene) may contribute to the pathophysiology of hypertension. However, because the number of subjects (especially African Americans) with the susceptible genotype in this study was small, these observations should be considered preliminary.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension susceptibilityIAGP 1601254 RGD 
hypertension susceptibilityISOATP1A2 (Homo sapiens)1601254; 1601254 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Atp1a2  (ATPase Na+/K+ transporting subunit alpha 2)

Genes (Mus musculus)
Atp1a2  (ATPase, Na+/K+ transporting, alpha 2 polypeptide)

Genes (Homo sapiens)
ATP1A2  (ATPase Na+/K+ transporting subunit alpha 2)


Additional Information