RGD Reference Report - Association of angiotensin II type 1 receptor gene polymorphism with carotid atherosclerosis. - Rat Genome Database

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Association of angiotensin II type 1 receptor gene polymorphism with carotid atherosclerosis.

Authors: Zhu, S  Meng, QH 
Citation: Zhu S and Meng QH, Clin Chem Lab Med. 2006;44(3):282-4.
RGD ID: 1601148
Pubmed: PMID:16519598   (View Abstract at PubMed)
DOI: DOI:10.1515/CCLM.2006.048   (Journal Full-text)

BACKGROUND: Polymorphisms of the angiotensin II type 1 receptor (AGTR1) gene are associated with essential hypertension and cardiovascular disease, but the correlation between AGTR1 A1166C polymorphism and carotid intima-media thickness (IMT) remains unclear. We sought to demonstrate correlation between AGTR1 gene polymorphism and carotid atherosclerosis in a Chinese population. METHOD: A total of 150 patients diagnosed with essential hypertension were included in this study. The AGTR1 A1166C polymorphism was detected by restriction analysis of the polymerase chain reaction product with Ddel digestion. Carotid IMT was measured by B-mode ultrasonography. RESULTS: The AC genotype frequency and the C1166 allele frequency of the AGTR1 gene in essential hypertensive patients were significantly higher than in controls (22.00% vs. 6.00% for AC, p < 0.01; 18.67% vs. 8.00% for the C allele, p < 0.05). Hypertensive subjects with the AC genotype had increased carotid artery IMT and IMT/D (common carotid artery diameter) ratio compared with the AA genotype (IMT 1.14 +/- 0.39 vs. 0.88 +/- 0.16, p < 0.05; IMT/D 14.08 +/- 2.88 vs. 10.51 +/- 1.94, p < 0.01). CONCLUSION: These results suggest that the AGTR1 A1166C polymorphism is associated with essential hypertension and carotid atherosclerosis in a Chinese population.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
carotid artery disease susceptibilityIAGP 1601148associated with hypertension and DNA:polymorphism:3' utr:g.1166A>CRGD 
carotid artery disease susceptibilityISOAGTR1 (Homo sapiens)1601148; 1601148associated with hypertension and DNA:polymorphism:3' utr:g.1166A>CRGD 
hypertension susceptibilityIAGP 1601148DNA:polymorphism:3' utr:g.1166A>CRGD 
hypertension susceptibilityISOAGTR1 (Homo sapiens)1601148; 1601148DNA:polymorphism:3' utr:g.1166A>CRGD 

Objects Annotated

Genes (Rattus norvegicus)
Agtr1a  (angiotensin II receptor, type 1a)

Genes (Mus musculus)
Agtr1a  (angiotensin II receptor, type 1a)

Genes (Homo sapiens)
AGTR1  (angiotensin II receptor type 1)


Additional Information