RGD Reference Report - Haplotype analysis of the beta2 adrenergic receptor gene and risk of myocardial infarction in humans. - Rat Genome Database

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Haplotype analysis of the beta2 adrenergic receptor gene and risk of myocardial infarction in humans.

Authors: Zee, RY  Cook, NR  Reynolds, R  Cheng, S  Ridker, PM 
Citation: Zee RY, etal., Genetics. 2005 Mar;169(3):1583-7. Epub 2004 Nov 1.
RGD ID: 1601126
Pubmed: PMID:15520258   (View Abstract at PubMed)
PMCID: PMC1449541   (View Article at PubMed Central)
DOI: DOI:10.1534/genetics.104.037812   (Journal Full-text)

Polymorphisms in the beta2 adrenergic receptor (ADRB2), in particular G16R, Q27E, and T164I, have been implicated in the pathogenesis of cardiovascular and metabolic phenotypes. However, no prospective, genetic-epidemiological data are available on the risk of cardiovascular disease associated with these variants. Using DNA samples collected at baseline in a prospective cohort of 14,916 initially healthy American men, we evaluated the G16R, Q27E, and T164I polymorphisms among 523 individuals who subsequently developed myocardial infarction and among 2092 individuals who remained free of reported cardiovascular events during follow-up. The haplotype frequency distribution was significantly different among cases and controls (chi(2)(7d.f.) = 20.92, P = 0.0039). Haplotype-based logistic regression, adjusting for age, smoking, and randomized treatment group, indicated that G16-Q27-I164 (odds ratio 0.178, 95% C.I. 0.043-0.737, P = 0.017) and (non-G16-Q27)-T164 (odds ratio 1.235, 95% C.I. 1.031-1.480, P = 0.022) haplotypes were significantly associated with altered risk of myocardial infarction. These findings remained after further adjustment for BMI, history of hypertension, and presence or absence of diabetes. In conclusion, variation in haplotype frequencies for the beta2 adrenergic receptor gene was found to be associated with risk of myocardial infarction.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
myocardial infarction susceptibilityIAGP 1601126DNA:polymorphisms: :p.G16R more ...RGD 
myocardial infarction susceptibilityISOADRB2 (Homo sapiens)1601126; 1601126DNA:polymorphisms: :p.G16R more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adrb2  (adrenoceptor beta 2)

Genes (Mus musculus)
Adrb2  (adrenergic receptor, beta 2)

Genes (Homo sapiens)
ADRB2  (adrenoceptor beta 2)


Additional Information