RGD Reference Report - Association of the beta2-adrenergic receptor gene with essential hypertension in the non-Han Chinese Yi minority human population. - Rat Genome Database

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Association of the beta2-adrenergic receptor gene with essential hypertension in the non-Han Chinese Yi minority human population.

Authors: Wu, H  Tang, W  Li, H  Zhou, X  Yang, Y  Yu, H  Li, K  Xiao, C  Deng, AY 
Citation: Wu H, etal., J Hypertens. 2006 Jun;24(6):1041-7.
RGD ID: 1601123
Pubmed: PMID:16685203   (View Abstract at PubMed)
DOI: DOI:10.1097/01.hjh.0000226193.21311.e1   (Journal Full-text)

OBJECTIVE: The human beta2-adrenergic receptor (ADRB2) gene is a candidate for contributing to the pathophysiology of essential hypertension. The aims of the present study were to investigate the associations of differing single nucleotide polymorphisms (SNPs) and haplotypes of the ADRB2 gene promoter and coding regions with essential hypertension in genetically homogeneous Hani and Yi minority groups that are non-Han Chinese. METHODS: Four SNPs in the regulatory and seven SNPs in the coding region were genotyped in 271 essential hypertension individuals and 267 controls, and eight haplotypes in the regulatory and five haplotypes in the coding region were determined and tested for association using the likelihood test statistic. RESULTS: There were significant associations of essential hypertension with separate SNPs located in both the regulatory and coding regions in the Yi minority group. In contrast, no associations of essential hypertension were detected with any of single SNPs in the Hani minority group. There is a significant difference in haplotype frequency distributions between the hypertensive participants and the controls in two groups (P < 10). CONCLUSION: The results indicate that variants at the ADRB2 locus may play a role in the pathophysiology of hypertension specifically in the Yi minority group.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension susceptibilityIAGP 1601123DNA:polymorphismsRGD 
hypertension susceptibilityISOADRB2 (Homo sapiens)1601123; 1601123DNA:polymorphismsRGD 

Objects Annotated

Genes (Rattus norvegicus)
Adrb2  (adrenoceptor beta 2)

Genes (Mus musculus)
Adrb2  (adrenergic receptor, beta 2)

Genes (Homo sapiens)
ADRB2  (adrenoceptor beta 2)


Additional Information