RGD Reference Report - [Neuroprotective effect of electroacupuncture therapy on damaged cholinergic neurons in rats with Alzheimer's disease] - Rat Genome Database

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[Neuroprotective effect of electroacupuncture therapy on damaged cholinergic neurons in rats with Alzheimer's disease]

Authors: Tang, Y  Yu, SG  Luo, S  Han, T  Yin, HY 
Citation: Tang Y, etal., Zhong Xi Yi Jie He Xue Bao. 2006 Jul;4(4):374-7.
RGD ID: 1600851
Pubmed: PMID:16834974   (View Abstract at PubMed)

OBJECTIVE: To explore the neuroprotective effect of electroacupuncture therapy on damaged cholinergic neurons in hippocampus in aged rats with Alzheimer's disease (AD). METHODS: Thirty six aged male rats were randomly divided into normal control group, sham-operated group, untreated group and electroacupuncture group. Animal model of AD was established with fimbria-fornix transection. The rats in the electroacupuncture group received electroacupuncture on Baihui (DU 20), Yongquan (KI 1), Taixi (KI 3) and Xuehai (SP10). The activity of choline acetyltransferase (ChAT) in septal area of brain was detected by radioimmunoassay, and the protein expressions of nerve growth factor (NGF) and c-fos in CA3 region of hippocampus were detected by immunohistochemical assay. RESULTS: The ChAT activity and the expression levels of NGF and c-fos proteins in the electroacupuncture group were significantly higher than those in the untreated group. CONCLUSION: Electroacupuncture therapy can protect cholinergic neurons in hippocampus in aged rats with AD by means of promoting synthesis of c-fos protein and increasing the expression level of NGF.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  ISOChat (Rattus norvegicus)1600851; 1600851 RGD 
Alzheimer's disease  IEP 1600851 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Chat  (choline O-acetyltransferase)

Genes (Mus musculus)
Chat  (choline acetyltransferase)

Genes (Homo sapiens)
CHAT  (choline O-acetyltransferase)


Additional Information