RGD Reference Report - Profiles of connectin (titin) in atrophied soleus muscle induced by unloading of rats. - Rat Genome Database

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Profiles of connectin (titin) in atrophied soleus muscle induced by unloading of rats.

Authors: Goto, K  Okuyama, R  Honda, M  Uchida, H  Akema, T  Ohira, Y  Yoshioka, T 
Citation: Goto K, etal., J Appl Physiol. 2003 Mar;94(3):897-902. Epub 2002 Oct 11.
RGD ID: 1600443
Pubmed: PMID:12391127   (View Abstract at PubMed)
DOI: DOI:10.1152/japplphysiol.00408.2002   (Journal Full-text)

Responses of the properties of connectin molecules in the slow-twitch soleus (Sol) and fast-twitch extensor digitorum longus muscles of rats to 3 days of unloading with or without 3-day reloading were investigated. The wet weight (relative to body wt) of Sol, not of extensor digitorum longus, in the unloaded group was significantly less than in the age-matched control (P < 0.05). Immunoelectron microscopic analyses showed that a monoclonal antibody against connectin (SM1) bound to the I-band region close to the edge of the A band at resting length and moved reversibly away from the Z line as the muscle fibers were stretched. In Sol, the displacement of the SM1-bound dense spots in response to stretching decreased after hindlimb suspension. There were no changes in the molecular weights and the percent distributions of alpha- and beta-connectin in both muscles after hindlimb suspension. A significant increment of percent beta-connectin in Sol was observed after 3 days of reloading after hindlimb suspension (P < 0.05). It is suggested that the elasticity of connectin filaments in the I-band region of the atrophied Sol fibers was reduced relative to that of the control fibers. The lack of the elasticity in atrophied muscle fibers may cause a decrease in contractile function.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
I band  IDA 1600443 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ttn  (titin)


Additional Information