RGD Reference Report - TTF-1, a homeodomain-containing transcription factor, regulates feeding behavior in the rat hypothalamus. - Rat Genome Database

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TTF-1, a homeodomain-containing transcription factor, regulates feeding behavior in the rat hypothalamus.

Authors: Kim, JG  Nam-Goong, IS  Yun, CH  Jeong, JK  Kim, ES  Park, JJ  Lee, YC  Kim, YI  Lee, BJ 
Citation: Kim JG, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):969-75. Epub 2006 Sep 1.
RGD ID: 1600159
Pubmed: PMID:16970909   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2006.08.147   (Journal Full-text)

TTF-1 is a member of the NKx family of homeodomain genes, and is required for morphogenesis and fetal diencephalon development. Our previous studies have shown that TTF-1 expression is maintained in some regions of the postnatal rat brain and transactivates the gene expression of several neuropeptides. In this study, a potential role for TTF-1 in the regulation of feeding behavior was identified. Immunohistochemical analysis showed that TTF-1 is present in several hypothalamic nuclei of the adult rat brain involved in the control of feeding behavior. Food deprivation for two days markedly increased the hypothalamic levels of TTF-1 mRNA and protein. Intracerebroventricular administration of an antisense TTF-1 oligodeoxynucleotide significantly decreased TTF-1 protein abundance in the hypothalamus. This TTF-1 decrease was followed by a significant decrease in neuropeptide Y mRNA content and an increase in proopiomelanocortin mRNA content, and in turn resulted in a decrease of the animal's food intake and body weight. These results suggest a novel role for TTF-1 in the regulation of feeding behavior in the rat hypothalamus.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
feeding behavior  IMP 1600159 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nkx2-1  (NK2 homeobox 1)


Additional Information