RGD Reference Report - SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells. - Rat Genome Database

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SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells.

Authors: Kim, J  Lo, L  Dormand, E  Anderson, DJ 
Citation: Kim J, etal., Neuron. 2003 Apr 10;38(1):17-31.
RGD ID: 1600051
Pubmed: PMID:12691661   (View Abstract at PubMed)

The mechanisms that establish and maintain the multipotency of stem cells are poorly understood. In neural crest stem cells (NCSCs), the HMG-box factor SOX10 preserves not only glial, but surprisingly, also neuronal potential from extinction by lineage commitment signals. The latter function is reflected in the requirement of SOX10 in vivo for induction of MASH1 and PHOX2B, two neurogenic transcription factors. Simultaneously, SOX10 inhibits or delays overt neuronal differentiation, both in vitro and in vivo. However, this activity requires a higher Sox10 gene dosage than does the maintenance of neurogenic potential. The opponent functions of SOX10 to maintain neural lineage potentials, while simultaneously serving to inhibit or delay neuronal differentiation, suggest that it functions in stem or progenitor cell maintenance, in addition to its established role in peripheral gliogenesis.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
stem cell differentiation  IEP 1600051 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sox10  (SRY-box transcription factor 10)


Additional Information