RGD Reference Report - Contacts between the commissural axons and the floor plate cells are mediated by nectins. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Contacts between the commissural axons and the floor plate cells are mediated by nectins.

Authors: Okabe, N  Shimizu, K  Ozaki-Kuroda, K  Nakanishi, H  Morimoto, K  Takeuchi, M  Katsumaru, H  Murakami, F  Takai, Y 
Citation: Okabe N, etal., Dev Biol. 2004 Sep 15;273(2):244-56.
RGD ID: 1599806
Pubmed: PMID:15328010   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ydbio.2004.05.034   (Journal Full-text)

During development of the central nervous system (CNS), commissural axons grow toward the ventral midline. After crossing the floor plate, they abruptly change their trajectory from the circumferential to the longitudinal axis. The contacts between the commissural axons and the floor plate cells are involved in this axonal guidance, but their mechanisms or structures have not fully been understood. In this study, we found that nectin-1 and -3, immunoglobulin-like cell-cell adhesion molecules, asymmetrically localized at the contact sites between the commissural axons and the floor plate cells, respectively. In vitro perturbation of the endogenous trans-interaction between nectin-1 and -3 caused abnormal fasciculation of the commissural axons and impairment of the contacts, and resulted in failure in longitudinal turns of the commissural axons at the contralateral sites of the rat hindbrain. These results indicate that the contacts between the commissural axons and the floor plate cells are mediated by the hetero-trans-interaction between nectin-1 and -3 and involved in regulation of the trajectory of the commissural axons.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
axon guidance  IMP 1599806 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein-containing complex binding  IMP 1599806heterodimerizationRGD 

Objects Annotated

Genes (Rattus norvegicus)
Nectin1  (nectin cell adhesion molecule 1)


Additional Information