RGD Reference Report - Transcriptional and posttranscriptional regulation of apolipoprotein E, A-I, and A-II gene expression in normal rat liver and during several pathophysiologic states. - Rat Genome Database

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Transcriptional and posttranscriptional regulation of apolipoprotein E, A-I, and A-II gene expression in normal rat liver and during several pathophysiologic states.

Authors: Panduro, A  Lin-Lee, YC  Chan, L  Shafritz, DA 
Citation: Panduro A, etal., Biochemistry. 1990 Sep 11;29(36):8430-5.
RGD ID: 1599161
Pubmed: PMID:2123716   (View Abstract at PubMed)

Assessment of the relative transcription rates and mRNA steady-state levels for apolipoprotein genes E, A-I, and A-II has been performed in normal rat liver, during liver regeneration and following induction of cirrhosis, as well as in rats with inherited analbuminemia associated with hyperlipidemia. Apo E exhibits primarily transcriptional control with an additional component of posttranscriptional control, whereas Apo A-I is controlled primarily at the posttranscriptional level, thus indicating that these genes are regulated independently. The level of control for Apo A-II has not been determined, because of difficulty experienced in measuring the transcription rate of this gene. During liver regeneration, cirrhosis, and analbuminemia, there is a marked increase in the ratio of Apo A-I to Apo E mRNA, resulting from an increase in the Apo A-I mRNA steady-state level and a decrease in Apo E mRNA. These changes are similar in the three pathophysiologic states and seem to occur through a combination of transcriptional and posttranscriptional mechanisms.

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Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
animal organ regeneration  IDA 1599161; 1599161 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Apoa1  (apolipoprotein A1)
Apoa2  (apolipoprotein A2)

Genes (Mus musculus)
Apoa1  (apolipoprotein A-I)

Genes (Homo sapiens)
APOA1  (apolipoprotein A1)

Objects referenced in this article
Gene APOA2 apolipoprotein A2 Homo sapiens
Gene Apoa2 apolipoprotein A-II Mus musculus

Additional Information