RGD Reference Report - Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. - Rat Genome Database

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Anthrax toxin receptor 2-dependent lethal toxin killing in vivo.

Authors: Scobie, HM  Wigelsworth, DJ  Marlett, JM  Thomas, D  Rainey, GJ  Lacy, DB  Manchester, M  Collier, RJ  Young, JA 
Citation: Scobie HM, etal., PLoS Pathog. 2006 Oct;2(10):e111.
RGD ID: 1599126
Pubmed: PMID:17054395   (View Abstract at PubMed)
PMCID: PMC1617126   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.ppat.0020111   (Journal Full-text)

Anthrax toxin receptors 1 and 2 (ANTXR1 and ANTXR2) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax toxin. The receptor-bound metal ion and PA residue D683 are critical for ANTXR1-PA binding. Since PA can bind to ANTXR2 with reduced affinity in the absence of metal ions, we reasoned that D683 mutant forms of PA might specifically interact with ANTXR2. We show here that this is the case. The differential ability of ANTXR1 and ANTXR2 to bind D683 mutant PA proteins was mapped to nonconserved receptor residues at the binding interface with PA domain 2. Moreover, a D683K mutant form of PA that bound specifically to human and rat ANTXR2 mediated killing of rats by anthrax lethal toxin, providing strong evidence for the physiological importance of ANTXR2 in anthrax disease pathogenesis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
anthrax disease  ISOAntxr2 (Rattus norvegicus)1599126 RGD 
anthrax disease  IDA 1599126 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding  IPIUniProtKB:P134231599126 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Antxr2  (ANTXR cell adhesion molecule 2)

Genes (Homo sapiens)
ANTXR2  (ANTXR cell adhesion molecule 2)


Additional Information