RGD Reference Report - Changes in amelogenesis in the rat incisor following short-term hypocalcaemia. - Rat Genome Database

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Changes in amelogenesis in the rat incisor following short-term hypocalcaemia.

Authors: Yamaguti, PM  Arana-Chavez, VE  Acevedo, AC 
Citation: Yamaguti PM, etal., Arch Oral Biol. 2005 Feb;50(2):185-8.
RGD ID: 1599092
Pubmed: PMID:15721149   (View Abstract at PubMed)
DOI: DOI:10.1016/j.archoralbio.2004.11.022   (Journal Full-text)

There is a relationship between hypocalcaemia and the enamel hypoplasia. Earlier studies in rats have reported a severe hypocalcaemia and enamel hypoplasia a month after thyro-parathyroidectomy (TPTX). The aims of this study were to look at earlier stages and to attempt to correlate morphological changes with alterations in the distribution of amelogenin. Twenty-five Wistar rats were, under anaesthesia, thyro-parathyroidectomized. Sham operated rats were included as controls. After 14, 30 or 57 days, the animals were reanesthatized and the tissues fixed by intracardiac perfusion of fixative. The lower incisors were processed for light microscopy and immunogold electron microscopy. After 14 days the thyro-parathyroidectomised rats were severely hypocalcaemic but amelogenesis was morphologically similar to controls. After 30 and 57 days, enamel defects were observed in the late secretory and early maturation stages in the thyro-parathyroidectomised rats. The immunocytochemical study revealed a concentration of stippled material immunolabelled for amelogenin at the secretory pole of the ameloblasts in the hypocalcaemic rats. The absence of enamel defects after 14 days suggests that this was an insufficient hypocalcaemic period to induce morphological alterations. The concentration of stippled material containing amelogenin suggests that alterations in matrix formation may be the basis of the morphological changes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
autosomal dominant hypocalcemia  ISOAmelx (Rattus norvegicus)1599092; 1599092 RGD 
autosomal dominant hypocalcemia  IEP 1599092 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to calcium ion  IEP 1599092 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Amelx  (amelogenin, X-linked)

Genes (Mus musculus)
Amelx  (amelogenin, X-linked)

Genes (Homo sapiens)
AMELX  (amelogenin X-linked)


Additional Information