RGD Reference Report - Adenylosuccinate lyase as an indicator of breast and prostate malignancies: a preliminary report. - Rat Genome Database

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Adenylosuccinate lyase as an indicator of breast and prostate malignancies: a preliminary report.

Authors: Reed, VL  Mack, DO  Smith, LD 
Citation: Reed VL, etal., Clin Biochem. 1987 Oct;20(5):349-51.
RGD ID: 1598760
Pubmed: PMID:3690833   (View Abstract at PubMed)

The high activity of adenylosuccinate (SAMP) lyase found in rat breast tumor, and its relative absence from normal rat breast tissue, suggests that it may serve as an indicator for human breast malignancy. Its activity has been measured in human breast tumors, both malignant and benign. The two were clearly separated with no overlap in activity between the malignant and benign tissues. Human prostate tissues were also examined for SAMP lyase. A cut-off level of 5 U/mL gave a false-positive rate of 11% with no false negatives. These results indicate that further work is warranted to determine the effectiveness of SAMP lyase as an indicator of breast and prostatic cancers.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
breast cancer severityIEP 1598760protein:increased activity:tumor (human)RGD 
breast cancer severityISOADSL (Homo sapiens)1598760; 1598760protein:increased activity:tumor (human)RGD 
prostate cancer severityIEP 1598760protein:increased activity:tumor (human)RGD 
prostate cancer severityISOADSL (Homo sapiens)1598760; 1598760protein:increased activity:tumor (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adsl  (adenylosuccinate lyase)

Genes (Mus musculus)
Adsl  (adenylosuccinate lyase)

Genes (Homo sapiens)
ADSL  (adenylosuccinate lyase)

Objects referenced in this article
Gene Adrb2 adrenoceptor beta 2 Rattus norvegicus

Additional Information