RGD Reference Report - Transient expression of MDR-1/P-glycoprotein in a model of partial cortical devascularization. - Rat Genome Database

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Transient expression of MDR-1/P-glycoprotein in a model of partial cortical devascularization.

Authors: Ramos, AJ  Lazarowski, A  Villar, MJ  Brusco, A 
Citation: Ramos AJ, etal., Cell Mol Neurobiol. 2004 Feb;24(1):101-7.
RGD ID: 1598554
Pubmed: PMID:15049514   (View Abstract at PubMed)

1. MDR-1 gene product confer to expressing cells the multidrug resistance phenotype to a broad range of drugs and xenobiotics. 2. It is known that different stress signals are able to induce MDR-1 expression through different promoters. 3. In a rat model of ischemia by partial cortical devascularization we studied the expression profile and the cellular localization of MDR-1 after 1, 3, 7, 14 and 28 days post lesion (DPL). 4. Using two different antibody clones we found that MDR-1 is expressed in cortical and striatal neurons ipsilateral to the devascularizing lesion, starting at 1DPL, showing a maximum at 7DPL to be thereafter reduced until undetectable levels by 28DPL. 5. MDR-1 expression may be defining a neuronal subset with a particular pharmacological profile.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
brain ischemia  IEP 1598554 RGD 
brain ischemia  ISOAbcb1b (Rattus norvegicus)1598554 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Abcb1b  (ATP-binding cassette, sub-family B member 1B)

Genes (Mus musculus)
Abcb1b  (ATP-binding cassette, sub-family B member 1B)

Objects referenced in this article
Gene ABCB1 ATP binding cassette subfamily B member 1 Homo sapiens

Additional Information