RGD Reference Report - Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats. - Rat Genome Database

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Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats.

Authors: Tovar, AR  Torre-Villalvazo, I  Ochoa, M  Elias, AL  Ortiz, V  Aguilar-Salinas, CA  Torres, N 
Citation: Tovar AR, etal., J Lipid Res. 2005 Sep;46(9):1823-32. Epub 2005 Jul 1.
RGD ID: 1598534
Pubmed: PMID:15995177   (View Abstract at PubMed)
DOI: DOI:10.1194/jlr.M500067-JLR200   (Journal Full-text)

Hepatic steatosis is commonly present during the development of insulin resistance, and it is a clear sign of lipotoxicity attributable in part to an accelerated lipogenesis. There is evidence that a soy protein diet prevents the overexpression of hepatic sterol-regulatory element binding protein-1 (SREBP-1), decreasing lipid accumulation. Therefore, the aim of the present work was to study whether a soy protein diet may prevent the development of fatty liver through the regulation of transcription factors involved in lipid metabolism in hyperinsulinemic and hyperleptinemic Zucker obese fa/fa rats. Serum and hepatic cholesterol and triglyceride levels, as well as VLDL-triglyceride and LDL-cholesterol, were significantly lower in rats fed soy protein than in rats fed a casein diet for 160 days. The reduction in hepatic cholesterol was associated with a low expression of liver X receptor-alpha and its target genes, 7-alpha hydroxylase and ABCA1. Soy protein also decreased the expression of SREBP-1 and several of its target genes, FAS, stearoyl-CoA desaturase-1, and delta5 and delta6 desaturases, decreasing lipogenesis even in the presence of hyperinsulinemia. Reduction in SREBP-1 was not associated with the presence of soy isoflavones. Finally, soy protein reduced SREBP-1 expression in adipocytes, preventing hypertrophy, which also helps prevent the development of hepatic lipotoxicity.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
steatotic liver disease  ISOAbca1 (Rattus norvegicus)1598534; 1598534 RGD 
steatotic liver disease  IEP 1598534 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Abca1  (ATP binding cassette subfamily A member 1)

Genes (Mus musculus)
Abca1  (ATP-binding cassette, sub-family A member 1)

Genes (Homo sapiens)
ABCA1  (ATP binding cassette subfamily A member 1)


Additional Information