RGD Reference Report - An insulin-like growth factor-I promoter polymorphism is associated with increased mortality in subjects with myocardial infarction in an elderly Caucasian population. - Rat Genome Database

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An insulin-like growth factor-I promoter polymorphism is associated with increased mortality in subjects with myocardial infarction in an elderly Caucasian population.

Authors: Yazdanpanah, M  Rietveld, I  Janssen, JA  Njajou, OT  Hofman, A  Stijnen, T  Pols, HA  Lamberts, SW  Witteman, JC  Van Duijn, CM 
Citation: Yazdanpanah M, etal., Am J Cardiol. 2006 May 1;97(9):1274-6. Epub 2006 Mar 10.
RGD ID: 1598421
Pubmed: PMID:16635594   (View Abstract at PubMed)
DOI: DOI:10.1016/j.amjcard.2005.11.069   (Journal Full-text)

We investigated whether an insulin-like growth factor I (IGF-I) promoter polymorphism is associated with excess mortality in elderly subjects with myocardial infarction (MI). This association was assessed in 7,983 subjects of the Rotterdam Study during 14 years of follow-up. Among 345 subjects who developed a MI, the risk of mortality was 1.49 times higher in the variant carriers of the IGF-I promoter polymorphism than in the nonvariant carriers (95% confidence interval 1.10 to 2.10, p = 0.02). The risk of death increased with the number of variant alleles. Our study suggests that genetically determined low IGF-I activity is an important determinant of mortality in subjects with MI.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
myocardial infarction severityIAGP 1598421 RGD 
myocardial infarction severityISOIGF1 (Homo sapiens)1598421; 1598421 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Igf1  (insulin-like growth factor 1)

Genes (Mus musculus)
Igf1  (insulin-like growth factor 1)

Genes (Homo sapiens)
IGF1  (insulin like growth factor 1)


Additional Information