RGD Reference Report - The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats. - Rat Genome Database

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The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats.

Authors: Kawabata, A  Kawao, N  Kuroda, R  Tanaka, A  Shimada, C 
Citation: Kawabata A, etal., Peptides. 2002 Jun;23(6):1181-3.
RGD ID: 1582348
Pubmed: PMID:12126749   (View Abstract at PubMed)

We examined if thrombin or a receptor-activating peptide for protease-activated receptor-1 (PAR-1), a thrombin receptor, could modulate nociception at peripheral levels. Intraplantar administration of PAR-1 activators, thrombin or TFLLR-NH(2), but not its inactive control FTLLR-NH(2) or a PAR-2 activator SLIGRL-NH(2), significantly attenuated the hyperalgesia in rats treated with carrageenan, although they had no effect on nociception in naive rats. The thrombin-PAR-1 system might thus act to attenuate nociception during inflammatory hyperalgesia.

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
abnormal nociception after inflammation  IDA 1582348 RGD 
Objects Annotated

Genes (Rattus norvegicus)
F2r  (coagulation factor II (thrombin) receptor)


Additional Information