RGD Reference Report - Ovariectomy increases Na+, K+-ATPase, acetylcholinesterase and catalase in rat hippocampus. - Rat Genome Database

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Ovariectomy increases Na+, K+-ATPase, acetylcholinesterase and catalase in rat hippocampus.

Authors: Monteiro, SC  Matte, C  Delwing, D  Wyse, AT 
Citation: Monteiro SC, etal., Mol Cell Endocrinol. 2005 May 31;236(1-2):9-16.
RGD ID: 1582147
Pubmed: PMID:15869839   (View Abstract at PubMed)
DOI: DOI:10.1016/j.mce.2005.03.006   (Journal Full-text)

In the present work we investigated the effect of ovariectomy on Na+, K+-ATPase and acetylcholinesterase (AChE) activities in rat hippocampus. We also studied some parameters of oxidative stress, namely total radical-trapping antioxidant potential (TRAP), thiobarbituric acid-reactive substances (TBA-RS), as well as the antioxidant enzyme activities superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities. Our hypothesis is that ovariectomy might cause alterations in essential enzyme activities necessary to brain normal functioning and that these chances could be caused by oxidative stress. Female adult Wistar rats were divided into three groups: (1) naive (control); (2) sham-operated; and (3) ovariectomized. Thirty days after ovariectomy rats were sacrificed. Results showed that rats subjected to ovariectomy presented a significant increase in Na+, K+-ATPase, AChE and CAT activities, but did not change the oxidative stress parameters studied when compared to sham or naive rats. Since ovariectomy mimics postmenopausal changes, our findings showing alteration in the activities of brain Na+, K+-ATPase, AChE and CAT may be related to problems in postmenopausal women.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
catalase activity  IDA 1582147 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cat  (catalase)


Additional Information