RGD Reference Report - The renin-angiotensin system: peptides and enzymes beyond angiotensin II. - Rat Genome Database

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The renin-angiotensin system: peptides and enzymes beyond angiotensin II.

Authors: Reudelhuber, TL 
Citation: Reudelhuber TL Curr Opin Nephrol Hypertens. 2005 Mar;14(2):155-9.
RGD ID: 1581849
Pubmed: PMID:15687842   (View Abstract at PubMed)

PURPOSE OF REVIEW: Although current pharmacotherapy for cardiovascular disease focuses on the inhibition of angiotensin II production and action, several other biologically active peptides are produced by the renin-angiotensin system. RECENT FINDINGS: Recent biochemical and physiological studies have shown that non-angiotensin II peptides, including angiotensins III, IV and 1-7, modulate blood pressure or cardiac function through novel mechanisms. Animal models support the notion that these peptides are physiologically important. SUMMARY: Although the role of these peptides has not yet resulted in the development of new therapies for the treatment of cardiovascular disease, they hold promise for identification of complimentary targets.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
renin-angiotensin cascade pathway   TAS 1581849; 1581849; 1581849; 1581849; 1581849 RGD 
renin-angiotensin cascade pathway   ISOMas1 (Mus musculus)1581849 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Lnpep  (leucyl and cystinyl aminopeptidase)
Mas1  (MAS1 proto-oncogene, G protein-coupled receptor)

Genes (Mus musculus)
Lnpep  (leucyl/cystinyl aminopeptidase)
Mas1  (MAS1 oncogene)

Genes (Homo sapiens)
LNPEP  (leucyl and cystinyl aminopeptidase)
MAS1  (MAS1 proto-oncogene, G protein-coupled receptor)


Additional Information