RGD Reference Report - Osteopontin gene haplotypes correlate with multiple sclerosis development and progression. - Rat Genome Database

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Osteopontin gene haplotypes correlate with multiple sclerosis development and progression.

Authors: Chiocchetti, A  Comi, C  Indelicato, M  Castelli, L  Mesturini, R  Bensi, T  Mazzarino, MC  Giordano, M  D'Alfonso, S  Momigliano-Richiardi, P  Liguori, M  Zorzon, M  Amoroso, A  Trojano, M  Monaco, F  Leone, M  Magnani, C  Dianzani, U 
Citation: Chiocchetti A, etal., J Neuroimmunol. 2005 Jun;163(1-2):172-8. Epub 2005 Apr 25.
RGD ID: 1581472
Pubmed: PMID:15885319   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jneuroim.2005.02.020   (Journal Full-text)

Osteopontin (OPN) is an inflammatory cytokine highly expressed in multiple sclerosis (MS) plaques. In a previous work, we showed that four OPN polymorphisms form three haplotypes (A, B, and C) and that homozygotes for haplotype-A display lower OPN levels than non-AA subjects. In this work, we evaluated the distribution of these OPN haplotypes in 425 MS patients and 688 controls. Haplotype-A homozygotes had about 1.5 lower risk of developing MS than non-AA subjects. Clinical analysis of 288 patients showed that AA patients displayed slower switching from a relapsing remitting to a secondary progressive form and milder disease with slower evolution of disability. MS patients displayed increased OPN serum levels, which were partly due to the increased frequency of non-AA subjects. Moreover in AA patients, OPN levels were higher than in AA controls and similar to those found in both non-AA patients and controls, which suggests a role of the activated immune response. These data suggest that OPN genotypes may influence MS development and progression due to their influence on OPN levels.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
multiple sclerosis  IAGP 1581472DNA more ...RGD 
multiple sclerosis  ISOSPP1 (Homo sapiens)1581472; 1581472DNA more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Spp1  (secreted phosphoprotein 1)

Genes (Mus musculus)
Spp1  (secreted phosphoprotein 1)

Genes (Homo sapiens)
SPP1  (secreted phosphoprotein 1)


Additional Information