RGD Reference Report - SULT1A1 polymorphism and esophageal cancer in males. - Rat Genome Database

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SULT1A1 polymorphism and esophageal cancer in males.

Authors: Wu, MT  Wang, YT  Ho, CK  Wu, DC  Lee, YC  Hsu, HK  Kao, EL  Lee, JM 
Citation: Wu MT, etal., Int J Cancer. 2003 Jan 1;103(1):101-4.
RGD ID: 1581448
Pubmed: PMID:12455060   (View Abstract at PubMed)
DOI: DOI:10.1002/ijc.10805   (Journal Full-text)

Sulfotransferase (SULT) 1A1 detoxifies and bioactivates a broad spectrum of substrates including xenobiotics. It has been suggested that the SULT1A1 his (histidine) allele, which is caused by a his for arg (arginine) substitution due to a G-->A transition at codon 213, carries a significantly higher risk for women to develop breast cancer. We investigated the association between the SULT1A1 arg/his genotype and esophageal cancer in men, 187 cases of esophageal squamous cell carcinoma and 308 controls from 3 medical centers in Taiwan. Cigarette smoking, areca chewing and alcohol consumption were the major risks for developing esophageal cancer. The frequencies of arg/his in cases and controls were 27.8% (52/187) and 11.0% (34/308), respectively (p < 0.0001). No subjects carried his/his. After adjusting for substance use and other covariates, individuals with arg/his had a 3.53-fold higher risk (95% CI = 2.12-5.87) of developing esophageal cancer than those with arg/arg. Unexpectedly, this positive association was found to be even stronger (adjusted OR = 4.04-4.80) among non-smokers, non-drinkers or non-chewers. Our findings suggest that the SULT1A1 his(213) allele is important in the development of esophageal cancer in men.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
esophagus squamous cell carcinoma  IAGP 1581448DNA:SNP:exon:p.R213H and 638G>A (human)RGD 
esophagus squamous cell carcinoma  ISOSULT1A1 (Homo sapiens)1581448; 1581448DNA:SNP:exon:p.R213H and 638G>A (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sult1a1  (sulfotransferase family 1A member 1)

Genes (Mus musculus)
Sult1a1  (sulfotransferase family 1A, phenol-preferring, member 1)

Genes (Homo sapiens)
SULT1A1  (sulfotransferase family 1A member 1)


Additional Information