RGD Reference Report - The role of osteopontin in foreign body giant cell formation. - Rat Genome Database

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The role of osteopontin in foreign body giant cell formation.

Authors: Tsai, AT  Rice, J  Scatena, M  Liaw, L  Ratner, BD  Giachelli, CM 
Citation: Tsai AT, etal., Biomaterials. 2005 Oct;26(29):5835-43. Epub 2005 Apr 21.
RGD ID: 1581336
Pubmed: PMID:15949549   (View Abstract at PubMed)
DOI: DOI:10.1016/j.biomaterials.2005.03.003   (Journal Full-text)

Foreign body giant cells (FBGCs) are a hallmark of the foreign body reaction caused by biomaterial implantation and are thought to contribute to biomaterial degradation and the duration of the response. Osteopontin (OPN) is a secreted, acidic matricellular protein with multiple phosphorylation sites that is highly expressed at sites of inflammation. OPN wildtype and knockout mice were implanted with poly(vinyl alcohol) sponges and explanted at 14 days. OPN knockout mice had more foreign body giant cells but fewer macrophages surrounding the implants than their wildtype counterparts. In an in vitro human FBGC assay, addition of soluble OPN was found to reduce macrophage fusion to giant cells. These are the first studies to show a direct inhibitory role of OPN in FBGC formation in response to implantation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Foreign-Body Reaction  ISOSpp1 (Mus musculus)1581336; 1581336 RGD 
Foreign-Body Reaction  IDA 1581336 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Spp1  (secreted phosphoprotein 1)

Genes (Mus musculus)
Spp1  (secreted phosphoprotein 1)

Genes (Homo sapiens)
SPP1  (secreted phosphoprotein 1)


Additional Information