RGD Reference Report - SNAP-25 in hippocampal CA3 region is required for long-term memory formation. - Rat Genome Database

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SNAP-25 in hippocampal CA3 region is required for long-term memory formation.

Authors: Hou, QL  Gao, X  Lu, Q  Zhang, XH  Tu, YY  Jin, ML  Zhao, GP  Yu, L  Jing, NH  Li, BM 
Citation: Hou QL, etal., Biochem Biophys Res Commun. 2006 Sep 8;347(4):955-62. Epub 2006 Jul 25.
RGD ID: 1581067
Pubmed: PMID:16870134   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2006.06.184   (Journal Full-text)

SNAP-25 is a synaptosomal protein of 25 kDa, a key component of synaptic vesicle-docking/fusion machinery, and plays a critical role in exocytosis and neurotransmitter release. We previously reported that SNAP-25 in the hippocampal CA1 region is involved in consolidation of contextual fear memory and water-maze spatial memory (Hou et al. European J Neuroscience, 20: 1593-1603, 2004). SNAP-25 is expressed not only in the CA1 region, but also in the CA3 region, and the SNAP-25 mRNA level in the CA3 region is higher than in the CA1 region. Here, we provide evidence that SNAP-25 in the CA3 region is also involved in learning/memory. Intra-CA3 infusion of SNAP-25 antisense oligonucleotide impaired both long-term contextual fear memory and water-maze spatial memory, with short-term memory intact. Furthermore, the SNAP-25 antisense oligonucleotide suppressed the long-term potentiation (LTP) of field excitatory post-synaptic potential (fEPSP) in the mossy-fiber pathway (DG-CA3 pathway), with no effect on paired-pulse facilitation of the fEPSP. These results are consistent with the notion that SNAP-25 in the hippocampal CA3 region is required for long-term memory formation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
long-term memory  IMP 1581067 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Snap25  (synaptosome associated protein 25)


Additional Information