RGD Reference Report - Single nucleotide polymorphisms in the interleukin-6 gene associated with blood pressure and atherosclerosis in a Japanese general population. - Rat Genome Database

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Single nucleotide polymorphisms in the interleukin-6 gene associated with blood pressure and atherosclerosis in a Japanese general population.

Authors: Tanaka, C  Mannami, T  Kamide, K  Takiuchi, S  Kokubo, Y  Katsuya, T  Kawano, Y  Miyata, T  Ogihara, T  Tomoike, H 
Citation: Tanaka C, etal., Hypertens Res. 2005 Jan;28(1):35-41.
RGD ID: 1580484
Pubmed: PMID:15969253   (View Abstract at PubMed)
DOI: DOI:10.1291/hypres.28.35   (Journal Full-text)

It is known that increased plasma levels of inflammatory markers, such as interleukin-6 (IL-6), are associated with atherosclerosis and myocardial infarction. The aim of this study was to reveal the contribution of the single nucleotide polymorphisms (SNPs) of the IL-6 gene on the blood pressure regulation and progression of atherosclerosis in a general Japanese population. In order to evaluate the potential implications of genetic variability of the IL-6 gene, we explored eight SNPs by direct sequencing for the entire coding region and the promoter region in the IL-6 gene and genotyped two SNPs, -636G > C in the promoter region and 1691C > G in intron 3, for a total of 2,421 Japanese subjects (1,162 men and 1,259 women). As a consequence, -636 G > C was significantly associated with systolic blood pressure (SBP) and carotid intima-media thickness (IMT) in women, and 1691C > G showed a relationship with SBP and carotid IMT in men after adjustment for all confounding factors. Although neither SNP had a significant correlation to the prevalence of hypertension, the haplotype frequency analysis indicated that the number of hypertensive men with a G allele at both -636 and 1691 was significantly greater than the number of nonhypertensive men with this combination. Thus, these two SNPs in the promoter region and intron 3 of the IL-6 gene might play a role in the blood pressure regulation and progression of atherosclerosis in the Japanese.

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Elevated systolic blood pressure sexual_dimorphismIAGP 1580484DNA:SNPs:promoter more ...RGD 
Increased carotid artery intimal medial thickness sexual_dimorphismIAGP 1580484DNA:SNPs:promoter more ...RGD 
Objects Annotated

Genes (Homo sapiens)
IL6  (interleukin 6)


Additional Information