RGD Reference Report - Childhood-onset schizophrenia and tryptophan hydroxylase gene polymorphism. - Rat Genome Database

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Childhood-onset schizophrenia and tryptophan hydroxylase gene polymorphism.

Authors: Sekizawa, T  Iwata, Y  Nakamura, K  Matsumoto, H  Suzuki, A  Suzuki, K  Sekine, Y  Takei, N  Minabe, Y  Mori, N 
Citation: Sekizawa T, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128(1):24-6.
RGD ID: 1580466
Pubmed: PMID:15211625   (View Abstract at PubMed)
DOI: DOI:10.1002/ajmg.b.30009   (Journal Full-text)

We explored the relationship between the tryptophan hydroxylase gene polymorphism and susceptibility to childhood-onset schizophrenia in a Japanese sample. Subjects were 51 Japanese patients who met DSM-IV criteria for schizophrenia before age 16 and 148 Japanese healthy controls. DNA was extracted from whole blood and genotyping was performed by PCR-RFLP using Nhe I. The frequency of the A allele was relatively higher in patients with childhood-onset schizophrenia than in controls (odds ratio, OR = 1.47, 95% CI = 0.97-2.37, P = 0.097). There was a nearly doubling of the risk for childhood-onset schizophrenia associated with the AA genotype compared to other genotype groups; OR = 1.97, 95% CI = 0.91-4.22, P = 0.058.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
schizophrenia  IAGP 1580466 RGD 
schizophrenia  ISOTPH1 (Homo sapiens)1580466; 1580466 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tph1  (tryptophan hydroxylase 1)

Genes (Mus musculus)
Tph1  (tryptophan hydroxylase 1)

Genes (Homo sapiens)
TPH1  (tryptophan hydroxylase 1)


Additional Information