RGD Reference Report - Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder in Chinese Han population. - Rat Genome Database

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Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder in Chinese Han population.

Authors: Li, J  Wang, Y  Zhou, R  Zhang, H  Yang, L  Wang, B  Faraone, SV 
Citation: Li J, etal., Am J Med Genet B Neuropsychiatr Genet. 2006 Mar 5;141(2):126-9.
RGD ID: 1580457
Pubmed: PMID:16389593   (View Abstract at PubMed)
DOI: DOI:10.1002/ajmg.b.30260   (Journal Full-text)

Attention deficit hyperactivity disorder (ADHD) is a severe behavioral disorder in children known to have a substantial genetic component. Prior studies have implicated serotonin genes in the etiology of ADHD but have not examined tryptophan hydroxylase (TPH), which is a rate-limiting enzyme in serotonin biosynthesis. The current study examined the relationship between the A218C and A-6526G polymorphisms of the TPH gene and ADHD. Three hundred sixty-two unrelated ADHD probands and their biological parents were recruited to participate in this study. No biased transmission of any allele of the two polymorphisms was observed using TDT analysis. However, haplotype analyses found that the rare 218A/-6526G haplotype was significantly not transmitted to probands with ADHD (chi(2) = 4.4995, P = 0.034), regardless of subtype. Although this finding for ADHD in the Chinese Han population.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
attention deficit hyperactivity disorder  IAGP 1580457DNA:polymorphisms: :-6526A>G and 218A>C (human)RGD 
attention deficit hyperactivity disorder  ISOTPH1 (Homo sapiens)1580457; 1580457DNA:polymorphisms: :-6526A>G and 218A>C (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tph1  (tryptophan hydroxylase 1)

Genes (Mus musculus)
Tph1  (tryptophan hydroxylase 1)

Genes (Homo sapiens)
TPH1  (tryptophan hydroxylase 1)


Additional Information