RGD Reference Report - Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding. - Rat Genome Database

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Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding.

Authors: Frade, JM 
Citation: Frade JM J Neurosci. 2005 Feb 9;25(6):1407-11.
RGD ID: 1580250
Pubmed: PMID:15703394   (View Abstract at PubMed)
PMCID: PMC6726010   (View Article at PubMed Central)
DOI: DOI:10.1523/JNEUROSCI.3798-04.2005   (Journal Full-text)

The intracellular domain of the p75 neurotrophin receptor (p75ICD) can be released by gamma-secretase in response to the previous activation of alpha-secretase by phorbol esters. However, ligand-dependent release of p75ICD has yet to be described. We show here that nerve growth factor can induce the release of p75ICD and facilitate its translocation to the nucleus in a gamma-secretase-dependent manner. This effect was observed in RN22 schwannoma cells cultured under serum-free conditions, as well as in Schwann cells, and it was mimicked by other neurotrophins, such as brain-derived neurotrophic factor or neurotrophin-3. Unlike other known examples of regulated intramembrane proteolysis, ligand-dependent release of p75ICD did not need the previous activation of alpha-secretase. These results suggest that nuclear translocation of p75ICD may represent a novel neurotrophin-mediated signaling pathway.

Objects referenced in this article
Gene Ngfr nerve growth factor receptor Rattus norvegicus

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