RGD Reference Report - Arginine vasopressin in the pathogenesis of febrile convulsion and temporal lobe epilepsy. - Rat Genome Database

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Arginine vasopressin in the pathogenesis of febrile convulsion and temporal lobe epilepsy.

Authors: Gulec, G  Noyan, B 
Citation: Gulec G and Noyan B, Neuroreport. 2002 Nov 15;13(16):2045-8.
RGD ID: 1579871
Pubmed: PMID:12438923   (View Abstract at PubMed)

We aimed to investigate the possible convulsant action of arginine vasopressin (AVP) in both a febrile convulsion model in rat pups and a temporal lobe epilepsy model in adult rats and to define the receptor type which mediates this effect. In rat pups, 125 ng V2 receptor antagonist significantly prevented hyperthermic seizures, but did not affect seizure latency. In adult rats, the only effective dose and agent was 125 ng V2 receptor antagonist, which prevented pilocarpine-induced status epilepticus, extended the status epilepticus latency and improved the 24 h survival rate. These data suggest that AVP has a convulsant activity in febrile convulsions and also in seizures independent of fever, and this effect is mediated by V2 receptors.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Avp  (arginine vasopressin)

Genes (Mus musculus)
Avp  (arginine vasopressin)

Genes (Homo sapiens)
AVP  (arginine vasopressin)


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