RGD Reference Report - Selective loss of resistant alleles at p15(INK4B) and p16(INK4A) genes in chemically-induced rat tongue cancers. - Rat Genome Database

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Selective loss of resistant alleles at p15(INK4B) and p16(INK4A) genes in chemically-induced rat tongue cancers.

Authors: Ogawa, K  Tanuma, JI  Hirano, M  Hirayama, Y  Semba, I  Shisa, H  Kitano, M 
Citation: Ogawa K, etal., Oral Oncol. 2006 Mar 7;.
RGD ID: 1578522
Pubmed: PMID:16527513   (View Abstract at PubMed)
DOI: DOI:10.1016/j.oraloncology.2005.11.011   (Journal Full-text)

We previously reported that susceptibility to 4-nitroquinoline 1-oxide (4NQO)-induced tongue cancer in Dark-Agouti (DA) and Wistar/Furth (WF) rats was determined by a number of quantitative trait loci. In this article, we further scrutinized one of the quantitative trait loci at a suggestive level on rat chromosome 5. Analyzing a DNA panel of 130 (DAxWF) F2 rats treated with 4NQO showed a quantitative trait loci, containing p15(INK4B) and p16(INK4A). To study the possible relevance of these genes in the development of tongue cancer, we examined 45 4NQO-induced tongue cancers in 100 (DAxWF) F1 rats for loss of heterozygosity. The incidence of loss of heterozygosity at p15(INK4B) and p16(INK4A) genes in large advanced tongue cancers was 37.8% and 40.0%, respectively, and the WF allele was selectively lost. Accumulation of loss of heterozygosity and methylation of the promoter regions in the tumour suppressor genes in advanced tumours suggests that they may play a role in tongue cancer progression.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Tongue Neoplasms  ISOCdkn2a (Rattus norvegicus)1578522; 1578522DNA:loss of heterozygosityRGD 
Tongue Neoplasms  ISOCdkn2b (Rattus norvegicus)1578522; 1578522DNA:loss of heterozygosityRGD 
Tongue Neoplasms  IAGP 1578522; 1578522DNA:loss of heterozygosityRGD 
Tongue Neoplasms  IAGP 1578522 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
increased tongue tumor incidence  IDA 1578522 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Cdkn2a  (cyclin-dependent kinase inhibitor 2A)
Cdkn2b  (cyclin-dependent kinase inhibitor 2B)

Genes (Mus musculus)
Cdkn2a  (cyclin dependent kinase inhibitor 2A)
Cdkn2b  (cyclin dependent kinase inhibitor 2B)

Genes (Homo sapiens)
CDKN2A  (cyclin dependent kinase inhibitor 2A)
CDKN2B  (cyclin dependent kinase inhibitor 2B)

QTLs
Tcas11  (Tongue tumor susceptibility QTL 11)

Strains
DA  (DA)
WF/Kga  (Wistar-Furth)

Objects referenced in this article
QTL Tcas8 Tongue tumor susceptibility QTL 8 Rattus norvegicus

Additional Information