RGD Reference Report - Sympathetic hyperreactivity to air-jet stress in the chromosome 1 blood pressure quantitative trait locus congenic rats. - Rat Genome Database

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Sympathetic hyperreactivity to air-jet stress in the chromosome 1 blood pressure quantitative trait locus congenic rats.

Authors: Yamazato, M  Ohya, Y  Nakamoto, M  Sakima, A  Tagawa, T  Harada, Y  Nabika, T  Takishita, S 
Citation: Yamazato M, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20.
RGD ID: 1578503
Pubmed: PMID:16239369   (View Abstract at PubMed)
DOI: DOI:10.1152/ajpregu.00610.2005   (Journal Full-text)

A chromosome 1 blood pressure quantitative trait locus (QTL) was introgressed from the stroke-prone spontaneously hypertensive rats (SHRSP) to Wistar-Kyoto (WKY) rats. This congenic strain (WKYpch1.0) showed an exaggerated pressor response to both restraint and cold stress. In this study, we evaluated cardiovascular and sympathetic response to an air-jet stress and also examined the role of the brain renin-angiotensin system (RAS) in the stress response of WKYpch1.0. We measured mean arterial pressure (MAP), heart rate (HR), and renal sympathetic nerve activity (RSNA) responses to air-jet stress in WKYpch1.0, WKY, and SHRSP. We also examined effects of intracerebroventricular administration of candesartan, an ANG II type 1 receptor blocker, on MAP and HR responses to air-jet stress. Baseline MAP in the WKYpch1.0 and WKY rats were comparable, while it was lower than that in SHRSP rats. Baseline HR did not differ among the strains. In WKYpch1.0, air-jet stress caused greater increase in MAP and RSNA than in WKY. The increase in RSNA was as large as that in SHRSP, whereas the increase in MAP was smaller than in SHRSP. Intracerebroventricular injection of a nondepressor dose of candesartan inhibited the stress-induced pressor response to a greater extent in WKYpch1.0 than in WKY. Intravenous injection of phenylephrine caused a presser effect comparable between WKYpch1.0 and WKY. These results suggest that the chromosome 1 blood pressure QTL congenic rat has a sympathetic hyperreactivity to an air-jet stress, which causes exaggerated pressor responses. The exaggerated response is at least partly mediated by the brain RAS.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
anxiety disorder  IDA 1578503 RGD 
hypertension MODEL: spontaneousIAGP 1578503compared to control strain WKY/IzmRGD 
hypertension MODEL: controlIAGP 1578503compared to hypertensive strain SHRSP/IzmRGD 
Stress-Induced Hypertension inducedIAGPair-jet exposure1578503compared to control strain WKY/IzmRGD 
Stress-Induced Hypertension inducedIAGPair-jet exposure1578503compared to hypertensive strain SHRSP/IzmRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
abnormal renal sympathetic nerve activity inducedIAGPair-jet exposure1578503compared to hypertensive strain SHRSP/IzmRGD 
abnormal response of heart to induced stress inducedIAGPair-jet exposure1578503compared to control strain WKY/IzmRGD 
abnormal systemic arterial blood pressure regulation susceptibilityIAGP 1578503compared to control strain WKY/IzmRGD 
decreased mean systemic arterial blood pressure susceptibilityIAGP 1578503compared to hypertensive strain SHRSP/IzmRGD 
decreased renal sympathetic nerve activity inducedIAGPair-jet exposure1578503compared to hypertensive strain SHRSP/IzmRGD 
decreased susceptibility to hypertension susceptibilityIAGP 1578503; 1578503compared to hypertensive strain SHRSP/IzmRGD 
hypertension susceptibilityIAGP 1578503compared to control strain WKY/IzmRGD 
increased heart rate  IAGP 1578503 RGD 
increased heart rate  IAGPair-jet exposure1578503compared to control strain WKY/IzmRGD 
increased mean systemic arterial blood pressure susceptibilityIAGP 1578503compared to control strain WKY/IzmRGD 
increased renal sympathetic nerve activity inducedIAGPair-jet exposure1578503compared to control strain WKY/IzmRGD 
increased renal sympathetic nerve activity  IAGP 1578503 RGD 
increased renal sympathetic nerve activity  IAGP 1578503compared to control strain WKY/IzmRGD 
increased susceptibility to hypertension susceptibilityIAGP 1578503compared to control strain WKY/IzmRGD 
increased systemic arterial blood pressure  IAGP 1578503 RGD 

Objects Annotated

QTLs
Stresp23  (Stress response QTL 23)

Strains
SHRSP/Izm  (NA)
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm  (NA)
WKY/Izm  (Wistar-Kyoto)


Additional Information