RGD Reference Report - Lack of association between genetic variations of apo A-I-C-III-A-IV gene cluster and myocardial infarction in a sample of European male: ECTIM study. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Lack of association between genetic variations of apo A-I-C-III-A-IV gene cluster and myocardial infarction in a sample of European male: ECTIM study.

Authors: Kee, F  Amouyel, P  Fumeron, F  Arveiler, D  Cambou, JP  Evans, A  Cambien, F  Fruchart, JC  Ducimetiere, P  Dallongeville, J 
Citation: Kee F, etal., Atherosclerosis. 1999 Jul;145(1):187-95.
RGD ID: 1578442
Pubmed: PMID:10428310   (View Abstract at PubMed)

The goal of the present study was to compare the allele frequency of four polymorphisms at the apo A-I C-III A-IV cluster gene locus-ApoA-I: XmnI and PstI; ApoC-III: SstI; ApoA-IV: XbaI-between male patients who had had a myocardial infarction (n= 614) and matched controls (n = 764). The association with a number of lipid lipoprotein, apolipoprotein and lipoprotein particle variables was also assessed. Patients and subjects were recruited in Belfast, Lille, Strasbourg and Toulouse in the framework of the ECTIM study. In the control group, the frequencies of the different polymorphic alleles were homogeneous among recruitment centres suggesting the absence of any European North to South gradient for these cluster polymorphisms. There was no evidence for a significant difference in allelic distribution between cases and controls suggesting that apo A-I, C-III, A-IV gene cluster polymorphisms do not explain MI survival in this sample of European men. There was no statistically significant association between apo A-I C-III A-IV cluster gene polymorphisms and lipid, lipoprotein, apolipoprotein, and lipoprotein particle levels. In conclusion, in the ECTIM study, the apo A-I, C-III, A-IV gene cluster polymorphism is associated with neither circulating plasma variables nor MI survival.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
myocardial infarction no_associationIAGP 1578442DNA:polymorphismsRGD 
myocardial infarction no_associationIAGP 1578442DNA:mutation:intron:IVS2 (human)RGD 
myocardial infarction no_associationIAGP 1578442 RGD 
myocardial infarction no_associationISOAPOA1 (Homo sapiens)1578442; 1578442DNA:polymorphismsRGD 
myocardial infarction no_associationISOAPOA4 (Homo sapiens)1578442; 1578442DNA:mutation:intron:IVS2 (human)RGD 
myocardial infarction no_associationISOAPOC3 (Homo sapiens)1578442; 1578442 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Abnormal coronary artery morphology no_associationIAGP 1578442DNA:mutation:intron:IVS2RGD 
Objects Annotated

Genes (Rattus norvegicus)
Apoa1  (apolipoprotein A1)
Apoa4  (apolipoprotein A4)
Apoc3  (apolipoprotein C3)

Genes (Mus musculus)
Apoa1  (apolipoprotein A-I)
Apoa4  (apolipoprotein A-IV)
Apoc3  (apolipoprotein C-III)

Genes (Homo sapiens)
APOA1  (apolipoprotein A1)
APOA4  (apolipoprotein A4)
APOC3  (apolipoprotein C3)


Additional Information