RGD Reference Report - Identification of quantitative trait loci for cardiac hypertrophy in two different strains of the spontaneously hypertensive rat. - Rat Genome Database

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Identification of quantitative trait loci for cardiac hypertrophy in two different strains of the spontaneously hypertensive rat.

Authors: Inomata, H  Watanabe, T  Iizuka, Y  Liang, YQ  Mashimo, T  Nabika, T  Ikeda, K  Yanai, K  Gotoda, T  Yamori, Y  Isobe, M  Kato, N 
Citation: Inomata H, etal., Hypertens Res 2005 Mar;28(3):273-81.
RGD ID: 1554311
Pubmed: PMID:16097372   (View Abstract at PubMed)
DOI: DOI:10.1291/hypres.28.273   (Journal Full-text)

Cardiac hypertrophy and left ventricular hypertrophy are known to be substantially controlled by genetic factors. As an experimental model, we undertook genome-wide screens for cardiac mass in F2 populations bred from the stroke-prone spontaneously hypertensive rats (SHRSP) and normal spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) of a Japanese colony. Two F2 cohorts were independently produced: F2(SHRSP x WKY) (110 male and 110 female rats) and F2(SHR x WKY) (151 male rats). The ratio of heart weight to body weight (Hw/Bw) was evaluated at 12 months of age in F2(SHRSP x WKY) after salt-loading for 7 months, and at around 15 weeks of age in F2(SHR x WKY) who had been fed a normal rat chow diet. Subsequent to an initial screen with 251 markers in F2(SHRSP x WKY) male progeny, 170 and 161 markers were selected and characterized in F2(SHRSP x WKY) female progeny and F2(SHR x WKY) male progeny, respectively. Markers from four chromosomal regions showed suggestive or significant linkage to Hw/Bw. The strongest and the most consistent linkage was found in the vicinity of D3Mgh16 on rat chromosome (RNO) 3 (a maximal log of the odds score reached 4.0 to 6.6 across the F2 populations studied). In the other three regions on RNO6, RNO10 and RNO13, the degree of linkage was more prominent in either males or females. These data provide solid evidence for a "principal" RNO3 quantitative trait loci regulating Hw/Bw in SHRSP and SHR, and also suggest the possible presence of sexual dimorphism in regard to genetic susceptibility for cardiac hypertrophy.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Cardiomegaly  IAGP 1554311; 1554311; 1554311; 1554311; 1554311; 1554311 RGD 
Cardiomegaly  IAGP 1554311compared to WKY/TkyoRGD 
Cardiomegaly MODEL: spontaneousIAGP 1554311compared to WKY/TkyoRGD 
Cardiomegaly MODEL: controlIAGP 1554311compared to SHR/Tyko and SHRSP/TykoRGD 
hypertension susceptibilityIAGP 1554311compared to WKY/TkyoRGD 
hypertension MODEL: spontaneousIAGP 1554311compared to WKY/TkyoRGD 
hypertension MODEL: controlIAGP 1554311compared to SHR/Tyko and SHRSP/TykoRGD 
Left Ventricular Hypertrophy  IAGP 1554311; 1554311; 1554311; 1554311; 1554311; 1554311; 1554311; 1554311; 1554311; 1554311; 1554311; 1554311; 1554311; 1554311; 1554311; 1554311 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype


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Objects Annotated

QTLs
Bw100  (Body weight QTL 100)
Bw101  (Body weight QTL 101)
Bw102  (Body weight QTL 102)
Bw103  (Body weight QTL 103)
Bw104  (Body weight QTL 104)
Bw105  (Body weight QTL 105)
Bw106  (Body weight QTL 106)
Bw107  (Body weight QTL 107)
Bw55  (Body weight QTL 55)
Bw56  (Body weight QTL 56)
Bw57  (Body weight QTL 57)
Bw58  (Body weight QTL 58)
Bw59  (Body weight QTL 59)
Bw98  (Body weight QTL 98)
Bw99  (Body weight QTL 99)
Cm43  (Cardiac mass QTL 43)
Cm44  (Cardiac mass QTL 44)
Cm45  (Cardiac mass QTL 45)
Cm46  (Cardiac mass QTL 46)
Cm47  (Cardiac mass QTL 47)
Cm48  (Cardiac mass QTL 48)
Cm74  (Cardiac mass QTL 74)
Cm75  (Cardiac mass QTL 75)
Cm76  (Cardiac mass QTL 76)
Cm77  (Cardiac mass QTL 77)
Cm78  (Cardiac mass QTL 78)
Cm79  (Cardiac mass QTL 79)

Strains
SHR/Tkyo  (NA)
SHRSP/Tkyo  (NA)
WKY/Tkyo  (NA)


Additional Information