RGD Reference Report - Lineage is an epigenetic modifier of QTL influencing behavioral coping with stress. - Rat Genome Database

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Lineage is an epigenetic modifier of QTL influencing behavioral coping with stress.

Authors: Ahmadiyeh, N  Churchill, GA  Solberg, LC  Baum, AE  Shimomura, K  Takahashi, JS  Redei, EE 
Citation: Ahmadiyeh N, etal., Behav Genet 2005 Mar;35(2):189-98.
RGD ID: 1358767
Pubmed: PMID:15685431   (View Abstract at PubMed)
PMCID: PMC3764451   (View Article at PubMed Central)
DOI: DOI:10.1007/s10519-004-1018-5   (Journal Full-text)

A genome-wide scan was carried out on a segregating F2 population of rats derived from reciprocal intercrosses between two inbred strains of rats, Fisher 344 (F344) and Wistar Kyoto (WKY) that differ significantly in their behavioral coping responses to stress measured by the defensive burying (DB) test. The DB test measures differences in coping strategies by assaying an animal's behavioral response to an immediate threat. We have previously identified three X-linked loci contributing to the phenotypic variance in behavioral coping. Here we report on six significant autosomal quantitative trait loci (QTL) related to different behaviors in the DB test:one for the number of shocks received, three for number of prod approaches, one for latency to bury, and one pleiotropic locus affecting both approach and latency. These QTL contributing to different aspects of coping behaviors show that the effect of genotype on phenotype is highly dependent on lineage. The WKY lineage was particularly influential, with five out of the six QTL affecting coping behavior only in rats of the WKY lineage, and one locus affecting only those in the F344 lineage. Thus, epigenetic factors, primarily of WKY origin, may significantly modulate the genetic contribution to variance in behavioral responses to stress in the DB test.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
anxiety disorder  IAGP 1358767; 1358767; 1358767; 1358767; 1358767; 1358767 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Objects Annotated

QTLs
Stresp10  (Stress response QTL 10)
Stresp11  (Stress response QTL 11)
Stresp12  (Stress response QTL 12)
Stresp13  (Stress response QTL 13)
Stresp8  (Stress response QTL 8)
Stresp9  (Stress response QTL 9)

Strains
F344/NHsd  (F344/NHsd)
WKY/NHsd  (NA)

Objects referenced in this article
QTL Activ1 Activity QTL 1 Rattus norvegicus
QTL Bp141 Blood pressure QTL 141 Rattus norvegicus
QTL Despr1 Despair related QTL 1 Rattus norvegicus
QTL Despr12 Despair related QTL 12 Rattus norvegicus

Additional Information