RGD Reference Report - Association between the GABA(A) receptor alpha5 subunit gene locus (GABRA5) and bipolar affective disorder. - Rat Genome Database

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Association between the GABA(A) receptor alpha5 subunit gene locus (GABRA5) and bipolar affective disorder.

Authors: Papadimitriou, GN  Dikeos, DG  Karadima, G  Avramopoulos, D  Daskalopoulou, EG  Vassilopoulos, D  Stefanis, CN 
Citation: Papadimitriou GN, etal., Am J Med Genet 1998 Feb 7;81(1):73-80.
RGD ID: 1358630
Pubmed: PMID:9514592   (View Abstract at PubMed)

Genetic factors seem to play an important role in the pathogenesis of affective disorder. The candidate gene strategies are being used, among others, to identify the genes conferring vulnerability to the disease. The genes coding for the receptors of gamma-aminobutyric acid (GABA) have been proposed as candidates for affective disorder, since the GABA neurotransmitter system has been implicated in the pathogenesis of the illness. We examined the possible genetic association between the GABA(A) receptor alpha5 subunit gene locus (GABRA5) on chromosome 15 and affective disorder, in 48 bipolar patients (BP), 40 unipolar patients (UP), and 50 healthy individuals, age- and sex-matched to the patients. All patients and controls were unrelated Greeks. Diagnoses were made after direct interviews according to the DSM-IV and ICD-10 criteria. For the genotyping, a dinucleotide (CA) repeat marker was used. The polymerase chain reaction (PCR) products found were nine alleles with lengths between 272 and 290 base pairs (bp). The distribution of allelic frequencies of the GABRA5 locus differed significantly between BP patients and controls with the 282-bp allele found to be associated with BP affective disorder, while no such difference was observed between the groups of UP patients and controls nor between the two patient groups. The presence or absence of the 282-bp allele in the genotype of BP patients was not shown to influence the age of onset and the overall clinical severity, but was found to be associated with a preponderance of manic over depressive episodes in the course of the illness.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
bipolar disorder  IAGP 1358630 RGD 
bipolar disorder  ISOGABRA5 (Homo sapiens)1358630; 1358630 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gabra5  (gamma-aminobutyric acid type A receptor subunit alpha 5)

Genes (Mus musculus)
Gabra5  (gamma-aminobutyric acid type A receptor subunit alpha 5)

Genes (Homo sapiens)
GABRA5  (gamma-aminobutyric acid type A receptor subunit alpha5)


Additional Information