RGD Reference Report - Comorbid migraine with aura, anxiety, and depression is associated with dopamine D2 receptor (DRD2) NcoI alleles. - Rat Genome Database

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Comorbid migraine with aura, anxiety, and depression is associated with dopamine D2 receptor (DRD2) NcoI alleles.

Authors: Peroutka, SJ  Price, SC  Wilhoit, TL  Jones, KW 
Citation: Peroutka SJ, etal., Mol Med 1998 Jan;4(1):14-21.
RGD ID: 1358603
Pubmed: PMID:9513185   (View Abstract at PubMed)
PMCID: PMC2230268   (View Article at PubMed Central)

BACKGROUND: Unrelated individuals (n = 242) were interviewed directly for the presence of migraine, anxiety disorders, and major depression. MATERIALS AND METHODS: The data described in this study are derived from a clinical genetic relational database that was developed initially for the genetic analysis of migraine. Genotyping of the DRD2 NcoI C to T polymorphism located in exon 6 (His313His) was performed using previously described primers. RESULTS: A significantly increased incidence of migraine with aura (MWA), major depression, generalized anxiety disorder (GAD), panic attacks, and phobia was observed in individuals with the DRD2 NcoI C/C genotype compared with individuals with an DRD2 NcoI T allele. Specifically, 69% (91/131) of DRD2 NcoI C/C individuals in the present study met criteria for at least one of these neuropsychiatric disorders versus only 22% (4/18) of the DRD2 NcoI T/T individuals (Chi-square = 15.29; p < 0.00005). The DRD2 NcoI C allele frequency is significantly higher (Chi-square = 17.13; p < 0.00002) in individuals with MWA, anxiety disorders, and/or major depression (C allele frequency = 0.80) than in individuals who have none of these disorders (C allele frequency = 0.67). CONCLUSIONS: These data indicate that MWA, anxiety disorders, and major depression can be components of a distinct clinical syndrome associated with allelic variations within the DRD2 gene. Clinical recognition of this genetically based syndrome has significant diagnostic and therapeutic implications.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
anxiety disorder  IAGP 1358603DNA:snp:cds:p.H313H (human)RGD 
anxiety disorder  ISODRD2 (Homo sapiens)1358603; 1358603DNA:snp:cds:p.H313H (human)RGD 
depressive disorder  IAGP 1358603DNA:snp:cds:p.H313H (human)RGD 
depressive disorder  ISODRD2 (Homo sapiens)1358603; 1358603DNA:snp:cds:p.H313H (human)RGD 
migraine with aura  IAGP 1358603DNA:snp:cds:p.H313H (human)RGD 
migraine with aura  ISODRD2 (Homo sapiens)1358603; 1358603DNA:snp:cds:p.H313H (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Drd2  (dopamine receptor D2)

Genes (Mus musculus)
Drd2  (dopamine receptor D2)

Genes (Homo sapiens)
DRD2  (dopamine receptor D2)


Additional Information