RGD Reference Report - Cholecystokinin- and cholecystokinin-B-receptor gene polymorphisms in panic disorder. - Rat Genome Database

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Cholecystokinin- and cholecystokinin-B-receptor gene polymorphisms in panic disorder.

Authors: Hosing, VG  Schirmacher, A  Kuhlenbaumer, G  Freitag, C  Sand, P  Schlesiger, C  Jacob, C  Fritze, J  Franke, P  Rietschel, M  Garritsen, H  Nothen, MM  Fimmers, R  Stogbauer, F  Deckert, J 
Citation: Hosing VG, etal., J Neural Transm Suppl 2004;(68):147-56.
RGD ID: 1358454
Pubmed: PMID:15354400   (View Abstract at PubMed)

Panic disorder like other neuropsychiatric disorders is believed to be caused by multiple psychosocial and biological factors. Several lines of evidence point to a role for the peptide neurotransmitter cholecystokinin in the pathogenesis of panic disorder. We therefore determined the allele and genotype frequencies of a single nucleotide polymorphism in the CCK gene (-36C>T) and one CT repeat polymorphism in the CCK-B-receptor gene in a German panic disorder sample (n = 115 for CCK gene polymorphism, n = 111 for CCK-B-receptor polymorphism) and compared them with gender and age matched controls. The length of the polymorphic CT repeat alleles varies between 146 bp and 180 bp. We first analysed the results by a permutation test which provided evidence for heterogeneity between patients and controls (p=0.002). We then analysed the data as a di-allelic polymorphism with a short (146-162bp) and a long (164-180bp) allele and as a tetra-allelic polymorphism with 4 alleles (146-154bp, 156-162bp, 164-170bp, 172-180bp). In the di-allelic analysis as well as in the tetra-allelic analysis there was an excess of the longer allele (p = 0.001) or the two longer alleles (p = 0.041) respectively in patients with panic disorder. No difference between groups was observed for the -36C > T polymorphism. Our findings are consistent with the notion that genetic variation in the CCK neurotransmitter system contributes to the pathogenesis of panic disorder.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
panic disorder  IAGP 1358454 RGD 
panic disorder  ISOCCKBR (Homo sapiens)1358454; 1358454 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Abnormal fear-induced behavior  IAGP 1358454Converted from MP term to HP term and 5-26-2016RGD 
Objects Annotated

Genes (Rattus norvegicus)
Cckbr  (cholecystokinin B receptor)

Genes (Mus musculus)
Cckbr  (cholecystokinin B receptor)

Genes (Homo sapiens)
CCKBR  (cholecystokinin B receptor)


Additional Information