RGD Reference Report - ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family. - Rat Genome Database

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ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family.

Authors: Brandt, S  Jentsch, TJ 
Citation: Brandt S and Jentsch TJ, FEBS Lett 1995 Dec 11;377(1):15-20.
RGD ID: 1357169
Pubmed: PMID:8543009   (View Abstract at PubMed)

We cloned two novel members of the CLC chloride channel family from rat and human brain. ClC-6 is a 97-kDa protein, and ClC-7 a 89-kDa protein roughly 45% identical with ClC-6. Together they define a new branch of this gene family. Both genes are very broadly expressed, e.g. in brain, testes, muscle and kidney. In mouse embryos, both genes are expressed as early as day 7. While the human gene for ClC-6 is located on human chromosome 1p36 and shares this region with hClC-Ka and hClC-Kb, ClC-7 is on 16p13. ClC-6 has a highly conserved glycosylation site between transmembrane domains D8 and D9, while ClC-7 is the only known eukaryotic ClC protein which lacks this site. Hydropathy analysis indicates that domain D4 cannot serve as a transmembrane domain. Both ClC-6 and ClC-7 cannot be expressed as chloride channels in Xenopus oocytes, either singly or in combination.

Objects referenced in this article
Gene Clcn7 chloride voltage-gated channel 7 Rattus norvegicus

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