RGD Reference Report - Sex-specific and sex-independent quantitative trait loci for facets of the metabolic syndrome in WOKW rats. - Rat Genome Database

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Sex-specific and sex-independent quantitative trait loci for facets of the metabolic syndrome in WOKW rats.

Authors: Kloting, I  Kovacs, P  Van den Brandt, J 
Citation: Kloting I, etal., Biochem Biophys Res Commun 2001 Jun 1;284(1):150-6.
RGD ID: 1357168
Pubmed: PMID:11374884   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.2001.4932   (Journal Full-text)

WOKW rats develop a complete metabolic syndrome closely resembling human disease. Since genetic studies using male (WOKW x DA)F2 progeny showed that several independent genetic factors were involved, a polygenic basis for the syndrome in WOKW was assumed. However, because the metabolic syndrome in human clearly demonstrates sex differences, we have extended our study to include both male and female (WOKW x DA)F2 progeny in a genome-wide scan. Male- or female-specific quantitative trait loci (QTLs) were mapped for body weight, body mass index, adiposity index and serum insulin on chromosomes 1 and 5, serum triglycerides on chromosomes 4, 7, 11, and 16, serum total and high density lipoprotein cholesterol on chromosomes 3, 4, 5, 10, and 17, and serum leptin on chromosomes 8 and 16 as well as blood glucose and glucose tolerance (AUC) on chromosomes 3, 4 and 17. QTLs for both, males and females were only found for body weight on chromosome 1 and for serum total cholesterol on chromosome 3 and 10. These findings clearly demonstrate that there are sex-specific and sex-independent QTLs for facets of the metabolic syndrome in WOKW rats.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
familial hyperlipidemia  IAGP 1357168 RGD 
hyperinsulinism  IAGP 1357168compared to DA/KRGD 
Hypertriglyceridemia  IAGP 1357168 RGD 
Hypertriglyceridemia  IAGP 1357168compared to DA/KRGD 
Metabolic Syndrome  IAGP 1357168; 1357168; 1357168; 1357168; 1357168; 1357168 RGD 
obesity  IDA 1357168; 1357168; 1357168; 1357168; 1357168; 1357168; 1357168; 1357168; 1357168 RGD 
obesity  IAGP 1357168compared to DA/KRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype


Objects Annotated

QTLs
Bw41  (Body weight QTL 41)
Bw42  (Body weight QTL 42)
Bw43  (Body weight QTL 43)
Bw44  (Body weight QTL 44)
Bw45  (Body weight QTL 45)
Bw46  (Body weight QTL 46)
Bw62  (Body weight QTL62)
Slep3  (Serum leptin concentration QTL 3)
Slep4  (Serum leptin concentration QTL 4)
Stl14  (Serum triglyceride level QTL 14)
Stl17  (Serum triglyceride level QTL 17)

Strains
DA/K  (Dark Agouti/Karlsburg)
WOKW  (NA)


Additional Information