Role of Genetics, Hypertension (Goldblatt Kidney) and Carbohydrate Metabolism Disturbance on the Development of Diabetic Nephropathy
A.M., COHEN MD and E., ROSENMANN MD
The role of genetics, hyperglycemia, insulinemia and hypertension in the development of diffuse glomerulosclerosis (GS) in the Cohen diabetic rat was studied. The genetic factor(s) alone, without the presence of diabetic metabolic derangements, was not sufficient to induce GS. Hypertension, per se, was not the initiating factor in GS development but had a modulating effect, since in animals with hypertension the incidence of GS was not significantly greater, while the renal lesions were more significantly severe, X2 (d.f. = 1) 8.01704, P < 0.01. No significant correlation was found between spontaneous blood glucose levels or oral glucose tolerance and the presence or severity of the renal lesions. A significantly impaired response to oral glucose load (P< 0.01), and significantly lower spontaneous insulin levels (P< 0.01), were found in animals with GS.